Prenylflavonoids counteract ovariectomy-induced disturbances in rats

被引：1

作者：

Nowak, Beata ^{[1
]}

Matuszewska, Agnieszka ^{[1
]}

Poplonski, Jaroslaw ^{[2
]}

Nikodem, Anna ^{[3
]}

Filipiak, Jaroslaw ^{[3
]}

Tomanik, Magdalena ^{[4
]}

Dziewiszek, Wojciech ^{[1
]}

Danielewski, Maciej ^{[1
]}

Belowska-Bien, Kinga ^{[1
]}

Klobucki, Marek ^{[2
]}

Sordon, Sandra ^{[2
]}

Jedrzejuk, Diana ^{[5
]}

Ceremuga, Ireneusz ^{[6
]}

Trocha, Malgorzata ^{[1
]}

Sozanski, Tomasz ^{[1
]}

Piasecki, Tomasz

Bolanowski, Marek ^{[5
,7
]}

Huszcza, Ewa ^{[2
]}

Szelag, Adam ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Pharmacol, Ul J Mikulicza Radeckiego 2, PL-50345 Wroclaw, Poland

[2] Wroclaw Univ Environm & Life Sci, Dept Chem, Ul CK Norwida 25, PL-50375 Wroclaw, Poland

[3] Wroclaw Univ Sci & Technol, Dept Mech Mat & Biomed Engn, Fac Mech Engn, Ul I Lukasiewicza 7-9, PL-50371 Wroclaw, Poland

[4] Wroclaw Univ Sci & Technol, Fac Mech Engn, Cross Div Students Sci Circle Biomech, Ul I Lukasiewicza 7-9, PL-50371 Wroclaw, Poland

[5] Wroclaw Med Univ, Dept & Clin Endocrinol, Diabet & Isotope Therapy, Wyb Pasteura 4, PL-50367 Wroclaw, Poland

[6] Wroclaw Med Univ, Dept Med Biochem, Ul T Chalbinskego 10, PL-50367 Wroclaw, Poland

[7] Wroclaw Univ Environm, Dept Epizootiol & Clin Birds & Exot Anim, Fac Vet Med, Pl Grunwaldzki 45, PL-50366 Wroclaw, Poland

来源：

JOURNAL OF FUNCTIONAL FOODS | 2021年 / 86卷

关键词：

Functional food; Menopause; Nutraceuticals; Xantohumol; Flavonoids; HUMULUS-LUPULUS L; PHARMACOLOGICAL PROFILE; POTENT PHYTOESTROGEN; SKIN TEMPERATURE; WOMENS HEALTH; HOT FLASHES; IN-VITRO; XANTHOHUMOL; BONE; HOPS;

D O I：

10.1016/j.jff.2021.104742

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of the study was to investigate in animal model the influence of hops prenylflavonoids on hot flashes and bone loss. Xanthohumol (XN) and hop prenylflavonoids extract (HOP) restored twenty-four-hour variability of tail skin temperature in ovariectomized rats. Additionally XN and HOP increased femoral bone mineral density (BMD) (0.268 +/- 0.019 g/cm2 and 0.256 +/- 0.013 g/cm2 vs. 0.214 +/- 0.015 g/cm2). In micro-computed tomography (mCT) XN and HOP led to a thickening of trabeculae in femurs and vertebral bodies. HOP increased serum osteocalcin (OC) (222.86 +/- 39.62 pg/mL vs. 175.87 +/- 58.91 pg/mL) and decreased tartrate-resistant acid phosphatase (TRACP) (0.714 +/- 0.132 U/L vs. 1.251 +/- 0.304 U/L), whereas in XN only decreased TRACP (0.738 +/- 0.178 U/L). Results of our study showed that HOP and XN ameliorate ovariectomy induced disturbances in tail skin temperature (TST). Additionally, HOP exerts a mild protective effect on bone loss induced by decline in oestrogen level.

引用

页数：11

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