Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans

被引：25
作者：
Papaevgeniou, Nikoletta [1 ]
Chondrogianni, Niki [1 ]
机构：
[1] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece
来源：
CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 19期
关键词：
Aging; senescence; aggregation; age-related diseases; C; elegans; polyphenols; longevity; stress resistance; LIFE-SPAN EXTENSION; BETA (A-BETA(1-42))-INDUCED PARALYSIS; ROOIBOS ASPALATHUS-LINEARIS; INCREASES STRESS RESISTANCE; CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; TETRAHYDROXYSTILBENE GLUCOSIDE; PROTEASOME ACTIVATION; CRANBERRY EXTRACT; CORTICAL-NEURONS;
D O I：
10.2174/1381612824666180515145652
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Polyphenols constitute a group of compounds that have been highly investigated for their beneficial effects against various pathologic and non-pathologic conditions and diseases. Among their multi-faceted properties, their anti-oxidant potential nominates them as ideal protective candidates for conditions characterized by elevated levels of oxidative stress, including aging and age-related diseases. The nematode Caenorhabditis elegans is a multicellular model organism that is highly exploited in studies related to aging and age-associated pathologies. In this review, we will summarize studies where polyphenolic compounds have been tested for their anti-aging potential and their protective role against the progression of age-related diseases using C. elegans as their main model.
引用
收藏
页码：2107 / 2120
页数：14
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