Fabrication of nanofibrous tubular scaffolds for bone tissue engineering

被引：12

作者：

Chen, Shunyu ^{[1
]}

He, Zhihang ^{[1
]}

Xu, Guojie ^{[1
]}

Xiao, Xiufeng ^{[1
]}

机构：

[1] Fujian Normal Univ, Coll Chem & Chem Engn, Fuzhou 350007, Peoples R China

来源：

MATERIALS LETTERS | 2016年 / 182卷

关键词：

Biomaterials; Polymer; Centrifugation; Nanofibrous tubular scaffolds; Bone tissue engineering; Thermally induced phase separation; MESENCHYMAL STEM-CELLS; ARCHITECTURE; DIFFERENTIATION; FIBERS;

D O I：

10.1016/j.matlet.2016.07.015

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Nanofibrous tubular poly(L-lactic acid) (PLLA) scaffolds were fabricated by centrifugation combined with thermally induced phase separation technique using PLLA/1,4-dioxane/water ternary system, at input voltage of 4.00 V and phase separation temperature of -15 degrees C. Addition of sucrose led to the generation of porous scaffolds with interconnected pores. Input voltage was the crucial factor to generate nanofibrous tubular scaffold that mimicked the structural features of the biological systems. The surface of nanofibrous tubular scaffold provided a good environment for attachment and proliferation of MC3T3-E1 subclone 14 cells, exhibiting significant potential for bone tissue regeneration. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：289 / 293

页数：5

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