Association of Combinations of Polymorphisms in Fibroblast Growth Factor Receptor 2 Gene with Breast Cancer among Various Ethnic Groups

被引：0

作者：

Aitkhozhina, N. A. ^{[1
]}

Khanseitova, A. K. ^{[1
]}

Nigmatova, V. G. ^{[1
]}

Neupokoeva, A. S. ^{[1
]}

Sharafutdinova, D. A. ^{[1
]}

Ashirbekov, E. E. ^{[1
]}

Favorov, A. V. ^{[2
,3
,4
]}

Balmukhanov, T. S. ^{[1
]}

机构：

[1] Aitkhozhin Inst Mol Biol & Biochem, Alma Ata 050012, Kazakhstan

[2] Russian Acad Sci, Vavilov Inst Gen Genet, Moscow 119991, Russia

[3] Johns Hopkins Sch Med, Baltimore, MD 21205 USA

[4] Inst Genet & Select Ind Microorganisms, Moscow 117545, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2017年 / 53卷 / 09期

关键词：

breast cancer; polymorphism; FGFR2; gene; APSampler; Kazakhstan; GENOME-WIDE ASSOCIATION; MULTIPLE-SCLEROSIS; AFRICAN-AMERICAN; FGFR2; SUSCEPTIBILITY; POPULATION; VARIANTS; WOMEN; RISK;

D O I：

10.1134/S1022795417090022

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A search for association of polymorphisms in loci rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in fibroblast growth factor receptor 2 (FGFR2) gene was performed using the "case-control" method among the major ethnic groups of Kazakhstan. Restriction fragments length polymorphism analysis of DNA obtained from 495 Kazakh and 195 Russian women with breast cancer (BC) revealed no statistically significant differences compared with the control group (190 Kazakhs, 170 Russians). An assessment of combination associations of alleles and genotypes (patterns) with BC was performed using the APSampler algorithm. Association of risk type (OR > 1.4; P-Fischer < 0.05; P-permutation < 0.05) in the Kazakh group identified two patterns, including allele C at site rs2420946, while the T allele was present in four protective patterns (OR < 0.70). No significant association of the examined polymorphisms with BC risk in the Russian group was revealed.

引用

页码：1042 / 1047

页数：6

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