Emerging Therapeutic Targets and Agents for Glioblastoma Migrating Cells

被引：12
作者：
Di, Chunhui
Mattox, Austin K.
Harward, Stephen
Adamson, Cory [1 ]
机构：
[1] Duke Univ, Preston Robert Tisch Brain Tumor Ctr, Dept Surg Neurosurg, Durham, NC 27710 USA
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 07期
关键词：
Glioblastoma; tumor cell migration; AJAP; chemotherapy; FOCAL ADHESION KINASE; HUMAN BRAIN-TUMORS; PROMOTES GLIOMA INVASION; PROTEIN-TYROSINE KINASE; SIGNALING PATHWAYS; IN-VITRO; EXTRACELLULAR-MATRIX; STEM-CELLS; GENE-EXPRESSION; SMALL-MOLECULE;
D O I：
10.2174/187152010793498618
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma multiforme (GBM) is one of the most common and most aggressive types of primary brain tumors in humans. Even with aggressive surgical resections using state of the art preoperative and intraoperative neuroimaging, along with the most recent techniques in radiotherapy and chemotherapy, the prognosis for GBM patients remains dismal. Survival after diagnosis is about 12-14 months. The tumor cells which already have migrated into normal brain tissue beyond the surgical resection margin account for the inability to effectively treat this tumor. Understanding how to control the migration of GBM cells is paramount to future therapies. In this review, we will focus on the emerging targets and agents which are being exploited to inhibit the migration of glioma cells in GBM.
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收藏
页码：543 / 555
页数：13
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