Influenza vaccine in healthy children: a meta-analysis

被引：66
作者：
Negri, E
Colombo, C
Giordano, L
Groth, N
Apolone, G
La Vecchia, C
机构：
[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[2] Univ Milan, CF Ctr, Dept Pediat, I-20122 Milan, Italy
[3] Univ Milan, Ist Stat Med & Biometria, I-20133 Milan, Italy
来源：
VACCINE | 2005年 / 23卷 / 22期
关键词：
influenza vaccine; children; meta-analysis;
D O I：
10.1016/j.vaccine.2004.11.053
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We conducted a meta-analysis of 13 randomised clinical trials evaluating the efficacy of influenza vaccine in healthy children. Against culture-confirmed influenza the overall efficacy was 74% (95% confidence interval, CI, 57%-84%), 65% for inactivated and 80% for live-attenuated vaccine. Corresponding figures were 59% (95% CI 43%-71%), 63% and 54% for serologically-confirmed influenza, and 33% (95% CI 29%-36%), 33% and 34% for clinical illness. Influenza vaccine is effective in preventing laboratory-confirmed and clinical influenza in healthy children, with no clear difference between inactivated and live-attenuated vaccine. Data on infants and younger children were too scanty to allow separate assessment. (c) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：2851 / 2861
页数：11
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