Effect of HIV-1 infection and increasing immunosuppression on menstrual function

被引：20

作者：

Ezechi, Oliver C. ^{[1
]}

Jogo, Andrea ^{[4
]}

Gab-Okafor, Chidinma ^{[1
]}

Onwujekwe, Dan I. ^{[2
]}

Ezeobi, Paschal M. ^{[2
]}

Gbajabiamila, Titi ^{[2
]}

Adu, Rosemary A. ^{[2
]}

Audu, Rosemary A. ^{[3
]}

Musa, Adesola Z. ^{[2
]}

Salu, Olumuyiwa B. ^{[3
]}

Meschack, Emily ^{[3
]}

Herbertson, Ebiere ^{[2
]}

Odunukwe, Nkiru ^{[2
]}

Idigbe, Oni E. ^{[2
]}

机构：

[1] Nigerian Inst Med Res, Sexual & Reprod Hlth Res Unit, Lagos, Nigeria

[2] Nigerian Inst Med Res, HIV & TB Res Unit, Div Clin Sci, Lagos, Nigeria

[3] Nigerian Inst Med Res, Div Microbiol, Human Virol Lab, Lagos, Nigeria

[4] Fed Med Ctr, Dept Obstet & Gynaecol, Markurdi, Nigeria

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2010年 / 36卷 / 05期

关键词：

antiretroviral drug; HIV; AIDS; immunosuppression; menstrual abnormality; HUMAN-IMMUNODEFICIENCY-VIRUS; WOMEN; MEN;

D O I：

10.1111/j.1447-0756.2010.01253.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Aim: The aim of this study was to determine the prevalence, pattern and determinants of menstrual abnormalities in HIV-positive Nigerian women. Methods: A cross-sectional study was carried out involving 3473 (2549 HIV-seropositive and 924 seronegative) consecutive and consenting women seen at the HIV treatment centers at the Nigerian Institute of Medical Research, Lagos and the Federal Medical Centre, Markurdi. Results: The sociodemographic characteristics of the two groups were comparable, except for body mass index (BMI): the HIV-negative women (28.1 +/- 8.1) had statistically significantly (P < 0.005) higher BMI compared to the HIV-positive women (21.9 +/- 7.5). Menstrual abnormalities were significantly more common in women living with HIV/AIDS (29.1%) compared to the HIV-negative (18.9%) women (P < 0.001). The proportions of women in the two groups with intermenstrual bleeding, menorrhagia, hypermenorrhea, and postcoital bleeding were similar (P > 0.005), however amenorrhea, oligomenorrhea, irregular periods and secondary dysmenorrhea were more common in the HIV-positive women (P < 0.02). Primary dysmenorrhea was less common in HIV-positive women (P < 0.03). Among the HIV-positive women, menstrual dysfunction was more common in women living with HIV/AIDS with opportunistic infections, CD4 count < 200, not undertaking therapy, symptomatic disease and BMI < 20. However, after controlling for cofounders, only CD4 < 200 (odds ratio [OR], 3.65; 95% confidence interval [CI], 1.2-9.7), BMI < 20 (OR, 2.4; 95%CI, 1.3-3.5) and not taking antiretroviral drugs (OR, 2.05; CI, 1.7-6.5) were associated with amenorrhea, oligomenorrhea, irregular periods and secondary dysmenorrhea. Conclusion: HIV-positive women in this study experienced more menstrual abnormalities of amenorrhea, oligomenorrhea, and irregular periods compared to the HIV-negative controls. HIV-positive women with CD4 count < 200, BMI < 20 and who do not take antiretroviral drugs are at the greatest risk.

引用

页码：1053 / 1058

页数：6