Obesity and Atherosclerosis: Mechanistic Insights

被引：170

作者：

Lovren, Fina ^{[1
]}

Teoh, Hwee ^{[1
,2
]}

Verma, Subodh ^{[1
]}

机构：

[1] Univ Toronto, St Michaels Hosp, Keenan Res Ctr Biomed Sci, Div Cardiac Surg, Toronto, ON, Canada

[2] Univ Toronto, St Michaels Hosp, Div Endocrinol & Metab, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2015年 / 31卷 / 02期

关键词：

DIET-INDUCED OBESITY; MONOCYTE-DERIVED MACROPHAGES; PLASMA-PROTEIN ADIPONECTIN; BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; GUT MICROBIOTA; NITRIC-OXIDE; VISCERAL FAT;

D O I：

10.1016/j.cjca.2014.11.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases. A plethora of mechanisms, including abnormalities in lipid metabolism, insulin resistance, inflammation, endothelial dysfunction, adipokine imbalance, and inflammasome activation have been suggested to underlie the relationship between obesity and atherosclerosis. More recent data point toward an emerging role of impaired autophagy and altered gut microbiome homeostasis as potentially contributing factors. This review provides an overview of this area.

引用

页码：177 / 183

页数：7

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