Evidence from circular dichroism and from melting behavior for helix-inducing complexation of a designed β3-pentadecapeptide with DNA duplexes

被引：9

作者：

Kimmerlin, T ^{[1
]}

Namoto, K ^{[1
]}

Seebach, D ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2003年 / 86卷 / 06期

关键词：

D O I：

10.1002/hlca.200390167

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inspired by naturally occurring DNA-binding proteins and their artificial alpha-peptidic mimics reported to date, a research project was initiated aiming at creating a new class of beta-peptides capable of binding to and ultimately regulating the functions of DNA. As an initial foray, a beta(3)-pentadecapeptide 1, which bears H-bonding Asn side chains and positively charged Lys side chains, was designed and synthesized on the solid support. DNA-Complexation studies by means of circular dichroism and DNA-melting-temperature measurements revealed the first preliminary indications that support the existence of ordered interactions between beta-peptides and DNA.

引用

页码：2104 / 2109

页数：6

共 23 条

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