Comparative effect of topical application of lindane and permethrin on oxidative stress parameters in adult scabies patients

Objectives: The insecticides lindane and permethrin are commonly used for treatment of scabies. Animal studies have shown the presence of insecticide induced oxidative stress. Hence, this study was undertaken to assess and compare the effects of topical application of lindane and permethrin on oxidative stress parameters in scabies patients. Design and methods: Patients were alternatively assigned to treatment by either 1% lindane lotion or 5% permethrin cream. Blood samples were collected before and 12-14 h after the application of the drugs and evaluated for oxidative stress parameters and compared with healthy controls. Results: Serum malondialdehyde (MDA) levels, erythrocyte superoxide dismutase (SOD) and catalase (CAT) activity were significantly increased while blood glutathione (GSH) levels were significantly decreased in the lindane group as compared to controls and the permethrin group. The permethrin treated group showed a non significant alteration in the oxidative stress parameters. Conclusion: Topical application of lindane induced significant oxidative stress as compared to permethrin which appears to be a safer option for the treatment of scabies. (C) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.