Mathematical models of radiation action on living cells: From the target theory to the modern approaches. A historical and critical review

被引:72
作者
Bodgi, Larry [1 ,2 ,6 ]
Canet, Aurelien [1 ,3 ]
Pujo-Menjouet, Laurent [3 ]
Lesne, Annick [4 ,5 ,6 ]
Victor, Jean-Marc [4 ,5 ,6 ]
Foray, Nicolas [1 ,6 ]
机构
[1] Canc Res Ctr Lyon, INSERM, Radiobiol Grp, UMR 1052, F-69008 Lyon, France
[2] Univ St Joseph, Fac Sci, Beirut 11072050, Lebanon
[3] Univ Lyon 1, Inst Camille Jordan, F-69622 Villeurbanne, France
[4] Univ Paris 06, Sorbonne Univ, CNRS, Lab Phys Theor Mat Condensee,UMR 7600, F-75252 Paris, France
[5] Univ Montpellier, CNRS, Inst Genet Mol Montpellier, UMR 5535, F-34293 Montpellier, France
[6] Univ Paris 06, CNRS, GDR 3536, Nucl Architecture & Dynam, F-75252 Paris, France
关键词
DSB repair; Ionising radiation; Models of radiation action; Cell survival; Radiosensitivity; DOUBLE-STRAND BREAKS; DOSE HYPER-RADIOSENSITIVITY; X-RAYS; IONIZING-RADIATION; DNA-DAMAGE; SURVIVAL CURVES; GAMMA-FUNCTION; TISSUE-CELLS; REPAIR RATE; IN-VITRO;
D O I
10.1016/j.jtbi.2016.01.018
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cell survival is conventionally defined as the capability of irradiated cells to produce colonies. It is quantified by the clonogenic assays that consist in determining the number of colonies resulting from a known number of irradiated cells. Several mathematical models were proposed to describe the survival curves, notably from the target theory. The Linear-Quadratic (LQ) model, which is to date the most frequently used model in radiobiology and radiotherapy, dominates all the other models by its robustness and simplicity. Its usefulness is particularly important because the ratio of the values of the adjustable parameters, alpha and beta, on which it is based, predicts the occurrence of post-irradiation tissue reactions. However, the biological interpretation of these parameters is still unknown. Throughout this review, we revisit and discuss historically, mathematically and biologically, the different models of the radiation action by providing clues for resolving the enigma of the LQ model. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:93 / 101
页数:9
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