Two Antifungal Components Isolated from Fructus Psoraleae and Folium Eucalypti Globuli by Bioassay-Guided Purification

被引：30

作者：

Lau, Kit-Man ^{[1
]}

Fu, Lai-Hong ^{[2
]}

Cheng, Ling ^{[1
]}

Wong, Chun-Wai ^{[1
]}

Wong, Yin-Lai ^{[1
]}

Lau, Ching-Po ^{[1
]}

Han, Simon Quan-Bin ^{[1
]}

Chan, Paul Kay-Sheung ^{[2
]}

Fung, Kwok-Pui ^{[1
,3
]}

Lau, Clara Bik-San ^{[1
]}

Hui, Mamie ^{[2
]}

Leung, Ping-Chung ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2010年 / 38卷 / 05期

关键词：

Psoralea corylifolia; Eucalyptus globules; Bakuchiol; Macrocarpal C; Antifungal; Dermatophyte; ANTIMICROBIAL ACTIVITIES; BAKUCHIOL; TERBINAFINE; EXTRACTS; FABACEAE; FOOT;

D O I：

10.1142/S0192415X10008421

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variolii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro. This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.

引用

页码：1005 / 1014

页数：10

共 26 条

[1] Antioxidant activity of bakuchiol: Experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain [J].

Adhikari, S ;

Joshi, R ;

Patro, BS ;

Ghanty, TK ;

Chintalwar, GJ ;

Sharma, A ;

Chattopadhyay, S ;

Mukherjee, T .

CHEMICAL RESEARCH IN TOXICOLOGY, 2003, 16 (09) :1062-1069

[2]

[Anonymous], 2008, Reference method for broth dilution antifungal susceptibility testing of yeasts

[3] Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent [J].

Bapat, K ;

Chintalwar, GJ ;

Pandey, U ;

Thakur, VS ;

Sarma, HD ;

Samuel, G ;

Pillai, MRA ;

Chattopadhyay, S ;

Venkatesh, M .

APPLIED RADIATION AND ISOTOPES, 2005, 62 (03) :389-393

[4] A prospective epidemiologic survey on the prevalence of foot disease in Hong Kong [J].

Chan, MKT ;

Chong, LY .

JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 2002, 92 (08) :450-456

[5]

Jessup CJ, 2000, J CLIN MICROBIOL, V38, P341

[6] In vitro antimicrobial activities of bakuchiol against oral microorganisms [J].

Katsura, H ;

Tsukiyama, RI ;

Suzuki, A ;

Kobayashi, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (11) :3009-3013

[7]

Krenisky JM, 1999, BIOL PHARM BULL, V22, P1137, DOI 10.1248/bpb.22.1137

[8]

Lin CF, 2007, J FOOD DRUG ANAL, V15, P433

[9]

Lin Lie-Chwen, 2003, Chinese Pharmaceutical Journal (Taipei), V55, P77

[10] Antifungal Resistance Mechanisms in Dermatophytes [J].

Martinez-Rossi, Nilce M. ;

Peres, Nalu T. A. ;

Rossi, Antonio .

MYCOPATHOLOGIA, 2008, 166 (5-6) :369-383

← 1 2 3 →