Rational antibody-based HIV-1 vaccine design: current approaches and future directions

被引：167

作者：

Walker, Laura M. ^{[1
,2
]}

Burton, Dennis R. ^{[1
,2
,3
,4
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA

[3] MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA 02114 USA

[4] Harvard, Boston, MA 02114 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 03期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; NEUTRALIZING MONOCLONAL-ANTIBODIES; POLYVALENT DNA PRIME; ENVELOPE GLYCOPROTEIN; IN-VITRO; CELL REPERTOIRE; RHESUS MACAQUES; SHIV CHALLENGE; CHIMERIC VIRUS; TYPE-1; VACCINE;

D O I：

10.1016/j.coi.2010.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV, given the huge variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. Unfortunately, despite many efforts, the development of an immunogen that elicits bNAbs remains elusive. However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologies for the isolation of further antibodies, insights into the requirements for antibody-mediated protection, and novel vaccination approaches are providing grounds for renewed optimism.

引用

页码：358 / 366

页数：9

共 85 条

[1] Role of HIV membrane in neutralization by two broadly neutralizing antibodies [J].

Alam, S. Munir ;

Morelli, Marco ;

Dennison, S. Moses ;

Liao, Hua-Xin ;

Zhang, Ruijun ;

Xia, Shi-Mao ;

Rits-Volloch, Sophia ;

Sun, Li ;

Harrison, Stephen C. ;

Haynes, Barton F. ;

Chen, Bing .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (48) :20234-20239

[2] Protective immunity following vaccination [J].

Amanna, Ian J. ;

Messaoudi, Ilhem ;

Slifka, Mark K. .

HUMAN VACCINES, 2008, 4 (04) :316-319

[3] A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120 [J].

Astronomo, Rena D. ;

Lee, Hing-Ken ;

Scanlan, Christopher N. ;

Pantophlet, Ralph ;

Huang, Cheng-Yuan ;

Wilson, Ian A. ;

Blixt, Ola ;

Dwek, Raymond A. ;

Wong, Chi-Huey ;

Burton, Dennis R. .

JOURNAL OF VIROLOGY, 2008, 82 (13) :6359-6368

[4] MECHANISMS OF ANTIBODY-MEDIATED PROTECTION AGAINST LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION - MOTHER-TO-BABY TRANSFER OF HUMORAL PROTECTION [J].

BALDRIDGE, JR ;

BUCHMEIER, MJ .

JOURNAL OF VIROLOGY, 1992, 66 (07) :4252-4257

[5] Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope [J].

Barnetta, Susan W. ;

Srivastava, Indresh K. ;

Kan, Elaine ;

Zhou, Fengmin ;

Goodsell, Amanda ;

Cristillo, Anthony D. ;

Ferrai, Maria Grazia ;

Weiss, Deborah E. ;

Letvin, Norman L. ;

Montefiori, David ;

Pal, Ranajit ;

Vajdy, Michael .

AIDS, 2008, 22 (03) :339-348

[6] Evaluating the immunogenicity of a disulfide-stabilized, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1 [J].

Beddows, S ;

Schülke, N ;

Kirschner, M ;

Barnes, K ;

Franti, M ;

Michael, E ;

Ketas, T ;

Sanders, RW ;

Maddon, PJ ;

Olson, WC ;

Moore, JP .

JOURNAL OF VIROLOGY, 2005, 79 (14) :8812-8827

[7] Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus type 1 vaccine with or without gp120: A phase 2 study in higher- and lower-risk volunteers [J].

Belshe, RB ;

Stevens, C ;

Gorse, GJ ;

Buchbinder, S ;

Weinhold, K ;

Sheppard, H ;

Stablein, D ;

Self, S ;

McNamara, J ;

Frey, S ;

Flores, J ;

Excler, JL ;

Klein, M ;

El Habib, R ;

Duliege, AM ;

Harro, C ;

Corey, L ;

Keefer, M ;

Mulligan, M ;

Wright, P ;

Celum, C ;

Judson, F ;

Mayer, K ;

McKirnan, D ;

Marmor, M ;

Woody, G .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (09) :1343-1352

[8] Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge [J].

Bogers, Willy M. J. M. ;

Davis, David ;

Baak, Ilona ;

Kan, Elaine ;

Hofman, Sam ;

Sun, Yide ;

Mortier, Daniella ;

Lian, Ying ;

Oostermeijer, Herman ;

Fagrouch, Zahra ;

Dubbes, Rob ;

van der Maas, Martin ;

Mooij, Petra ;

Koopman, Gerrit ;

Verschoor, Ernst ;

Langedijk, Johannes P. M. ;

Zhao, Jun ;

Brocca-Cofano, Egidio ;

Robert-Guroff, Marjorie ;

Srivastava, Indresh ;

Barnett, Susan ;

Heeney, Jonathan L. .

VIROLOGY, 2008, 382 (02) :217-225

[9] Antibodies, viruses and vaccines [J].

Burton, DR .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (09) :706-713

[10] Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41 [J].

Cardoso, RMF ;

Zwick, MB ;

Stanfield, RL ;

Kunert, R ;

Binley, JM ;

Katinger, H ;

Burton, DR ;

Wilson, IA .

IMMUNITY, 2005, 22 (02) :163-173

← 1 2 3 4 5 6 7 8 9 →