F-prostanoid receptor regulation of fibroblast growth factor 2 signaling in endometrial adenocarcinoma cells

被引：32
作者：
Sales, Kurt J.
Boddy, Sheila C.
Williams, Alistair R. W.
Anderson, Richard A.
Jabbour, Henry N.
机构：
[1] Univ Edinburgh, MRC, Human Reprod Sci Unit, Queens Med Res Inst Dept Pathol, Edinburgh EH16 4TJ, Midlothian, Scotland
[2] Univ Edinburgh, Div Reprod & Dev Sci, Edinburgh EH16 4TJ, Midlothian, Scotland
来源：
ENDOCRINOLOGY | 2007年 / 148卷 / 08期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1210/en.2006-1517
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Prostaglandin (PG) F2 alpha is a potent bioactive lipid in the female reproductive tract, and exerts its function after coupling with its heptahelical G-protein-coupled receptor [F-series-prostanoid (FP) receptor] to initiate cell signaling and target gene transcription. In the present study, we found elevated expression of fibroblast growth factor (FGF) 2, FGF receptor 1 (FGFR1), and FP receptor, colocalized within the neoplastic epithelial cells of endometrial adenocarcinomas. We investigated a role for PGF2 alpha-FP receptor interaction in modulating FGF2 expression and signaling using an endometrial adenocarcinoma cell line stably expressing the FP receptor to the levels detected in endometrial adenocarcinomas (FPS cells) and endometrial adenocarcinoma tissue explants. PGF2 alpha-FP
引用
收藏
页码：3635 / 3644
页数：10
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