Haloacetylated enol ethers: 18 - Synthesis of alkyl 6-[azol-3(5)-yl]hexanoates

被引：17
作者：
Martins, MAP [1 ]
Bastos, GP [1 ]
Sinhorin, AP [1 ]
Zimmermann, NEK [1 ]
Rosa, A [1 ]
Brondani, S [1 ]
Emmerich, D [1 ]
Bonacorso, HG [1 ]
Zanatta, N [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Quim, Nucl Quim Heterociclos NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2003年 / 123卷 / 02期
关键词：
enones; isoxazoles; pyrazoles; 4,5-dihydroisoxazoles; alkyl hexanoates;
D O I：
10.1016/S0022-1139(03)00161-1
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A convenient method for the synthesis of eight alkyl 6-[4,5-dihydroisoxazol-3-yl(-pyrazol-3(5)-yl)]hexanoates from the cyclocondensation of methyl 10,10,10-trifluoro[chloro]-9-oxo-7-methoxydec-7-enoates and hydroxylamine hydrochloride or hydrazine hydrochloride, respectively, in ethanol as solvent is reported. The reaction of methyl 10,10,10-trichloro-9-oxo-7-methoxydec-7-enoates with hydrazines furnished the pyrazole derivatives with the simultaneous transformation of trichloromethyl to carboxyl group. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：249 / 253
页数：5
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