Caenorhabditis elegans 2007:: The premier model for the study of aging

被引：46
作者：
Johnson, Thomas E. [1 ]
机构：
[1] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 01期
关键词：
genetics of aging; aging models; inflammation; immune response; dietary restriction; protein synthesis; drugs; longevity mutants;
D O I：
10.1016/j.exger.2007.09.008
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
This is the 25th anniversary of the discovery of extended longevity mutants in Caenorhabditis elegans. About one hundred papers describing results from studies on C elegans in aging research appeared this year. Many themes were pursued including dietary restriction, daf-9 action, the role of proteolysis and autophagy, and the continued search for more Age mutants. I use the word "modulate" not "regulate" so as to be consistent with the evolutionary theory of aging, which is also consistent with the empirical findings of all extended longevity (Age) mutants. These Age mutants universally result from deficits in known physiologic systems, rather than in some process designed to kill the animal in old age. (C) 2007 Elsevier Inc. All rights reserved.
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页码：1 / 4
页数：4
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