Effect of sex hormones on eosinophilic inflammation in nasal mucosa

被引：104

作者：

Hamano, N ^{[1
]}

Terada, N ^{[1
]}

Maesako, K ^{[1
]}

Numata, T ^{[1
]}

Konno, A ^{[1
]}

机构：

[1] Chiba Univ, Sch Med, Dept Otorhinolaryngol, Chiba 280, Japan

来源：

ALLERGY AND ASTHMA PROCEEDINGS | 1998年 / 19卷 / 05期

关键词：

D O I：

10.2500/108854198778557773

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We examined the effects of sex hormones on the functions of eosinophils. Treatment of eosinophils with beta-estradiol significantly enhanced the eosinophil adhesion to human mucosal microvascular endothelial cells (HMMEC), and eosinophils stimulated by a combination of beta-estradiol and progesterone showed significant induced degranulation. On the other hand, testosterone significantly reduced the eosinophil adhesion to HMMEC and eosinophil viability. The experiments from this series of studies might provide a partial explanation for the aggravation of asthma and some forms of rhinitis that occurs during pregnancy.

引用

页码：263 / 269

页数：7

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