The Mitochondrial Prohibitin (PHB) Complex in C. elegans Metabolism and Ageing Regulation

被引：12
作者：
Lourenco, Artur B. [1 ]
Artal-Sanz, Marta [1 ,2 ]
机构：
[1] Univ Pablo Olavide Junta Andalucia, CSIC, Andalusian Ctr Dev Biol CABD, Carretera Utrera Km 1, Seville 41013, Spain
[2] Univ Pablo Olavide, Dept Mol Biol & Biochem Engn, Carretera Utrera Km 1, Seville 41013, Spain
来源：
METABOLITES | 2021年 / 11卷 / 09期
基金：
欧洲研究理事会;
关键词：
mitochondrial prohibitin complex; metabolism; ageing; PROTEIN-KINASE B; LIFE-SPAN; ENDOPLASMIC-RETICULUM; INSULIN-RECEPTOR; STRESS-RESPONSE; LIPID DROPLETS; CELL FUNCTION; LONGEVITY; TREHALOSE; NEMATODE;
D O I：
10.3390/metabo11090636
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mitochondrial prohibitin (PHB) complex, composed of PHB-1 and PHB-2, is an evolutionarily conserved context-dependent modulator of longevity. This extremely intriguing phenotype has been linked to alterations in mitochondrial function and lipid metabolism. The true biochemical function of the mitochondrial PHB complex remains elusive, but it has been shown to affect membrane lipid composition. Recent work, using large-scale biochemical approaches, has highlighted a broad effect of PHB on the C. elegans metabolic network. Collectively, the biochemical data support the notion that PHB modulates, at least partially, worm longevity through the moderation of fat utilisation and energy production via the mitochondrial respiratory chain. Herein, we review, in a systematic manner, recent biochemical insights into the impact of PHB on the C. elegans metabolome.
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页数：13
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