Reduction of Immunogenicity of Anthrax Vaccines Subjected to Thermal Stress, as Measured by a Toxin Neutralization Assay

被引：12

作者：

Castelan-Vega, Juan ^{[1
]}

Corvette, Laura ^{[1
]}

Sirota, Lev ^{[1
]}

Arciniega, Juan ^{[1
]}

机构：

[1] Ctr Biol Evaluat & Res, Rockville, MD 20852 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2011年 / 18卷 / 02期

关键词：

PROTECTIVE ANTIGEN; LETHAL TOXIN; BACILLUS-ANTHRACIS; INACTIVATION; VALIDATION;

D O I：

10.1128/CVI.00267-10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge.

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收藏

页码：349 / 351

页数：3

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