Reduction of Immunogenicity of Anthrax Vaccines Subjected to Thermal Stress, as Measured by a Toxin Neutralization Assay

被引:12
作者
Castelan-Vega, Juan [1 ]
Corvette, Laura [1 ]
Sirota, Lev [1 ]
Arciniega, Juan [1 ]
机构
[1] Ctr Biol Evaluat & Res, Rockville, MD 20852 USA
关键词
PROTECTIVE ANTIGEN; LETHAL TOXIN; BACILLUS-ANTHRACIS; INACTIVATION; VALIDATION;
D O I
10.1128/CVI.00267-10
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge.
引用
收藏
页码:349 / 351
页数:3
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