Gonadotrophin replacement for induction of fertility in hypogonadal men

被引：71

作者：

Dwyer, Andrew A. ^{[1
]}

Raivio, Taneli ^{[2
,3
]}

Pitteloud, Nelly ^{[1
,4
]}

机构：

[1] CHU Vaudois, Endocrinol Diabet & Metab Serv, CH-1011 Lausanne, Switzerland

[2] Univ Helsinki, Inst Biomed Physiol, Helsinki, Finland

[3] Helsinki Univ Cent Hosp, Childrens Hosp, Helsinki, Finland

[4] Univ Lausanne, Fac Biol & Med, CHU Vaudois, Inst Physiol & Endocrinol,Diabet & Metab Serv, CH-1011 Lausanne, Switzerland

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2015年 / 29卷 / 01期

关键词：

GnRH deficiency; Kallmann syndrome; hypogonadotrophic hypogonadism; male fertility; gonadotrophin therapy; fertility treatment; fertility outcomes; HUMAN CHORIONIC-GONADOTROPIN; FOLLICLE-STIMULATING-HORMONE; INTRACYTOPLASMIC SPERM INJECTION; HUMAN MENOPAUSAL GONADOTROPIN; RECOMBINANT HUMAN FSH; ANTIMULLERIAN HORMONE; LUTEINIZING-HORMONE; KALLMANN-SYNDROME; MALE-INFERTILITY; AZOOSPERMIC MEN;

D O I：

10.1016/j.beem.2014.10.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Congenital hypogonadotrophic hypogonadism (CHH) is a rare form of infertility caused by deficient secretion or action of gonadotrophin-releasing hormone. There is no consensus regarding the optimal approach to fertility treatment in CHH men. In most cases, appropriate hormonal treatment with human chorionic gonadotrophin with or without follicle stimulating hormone will induce testicular development, spermatogenesis and fertility. Recent studies have examined sequential treatment with FSH pretreatment to optimize fertility outcomes in severely affected CHH patients. This paper reviews historical and recent literature to summarize the current evidence on therapeutic approaches for CHH men seeking fertility. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：91 / 103

页数：13

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