Bromination of 7-O-Substituted-8-methyl-coumarins and 4H-Chromen-4-ones with N-Bromosuccinimide in CCl4

被引：0

作者：

Cheng, Ming ^{[1
]}

Qiu, Ya ^{[1
]}

Liu, Hongshan ^{[1
]}

Xia, Peng ^{[1
]}

Chen, Ying ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 30卷 / 11期

关键词：

7-O-substituted-8-methyl-coumarin; 7-O-substituted-8-methyl-4H-chromen-4-one; Seco-DCK; Seco-DCP; bromination; ANTI-AIDS AGENTS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bromination of 7-O-substituted-8-methyl-coumarins and 4H-chromen-4-ones, two key intermediates in the synthesis of Seco-DCK and Seco-DCP analogues, with N-bromosuccinimide in CCl4 is reported The experimentation showed that the selectivity of bromination of 8-methyl is more complicated than that of common benzyls, due to the presence of multiple reactive sites in these two title substrates Diversity of the products was discussed and the reasonable explanation for which was provided The bulky group of 7-O-substitutes, its electric property as well as addition of free radical initiator could affect the selectivity and the yield of bromination of 8-methyl The desired 8-bromomethyl products could be obtained in mild yields under optimized condition

引用

页码：1737 / 1741

页数：5

共 5 条

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