Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM

被引：242

作者：

Bomsel, M ^{[1
]}

Heyman, M

Hocini, H

Lagaye, S

Belec, L

Dupont, C

Desgranges, C

机构：

[1] ICGM, INSERM, U332, F-75014 Paris, France

[2] Fac Necker Enfants Malad, INSERM, CJF 98X, F-75730 Paris, France

[3] Hop Broussais, INSERM, U430, F-75014 Paris, France

[4] Inst Pasteur, F-75015 Paris, France

[5] Hop St Vincent de Paul, F-74014 Paris, France

[6] INSERM, U271, F-69424 Lyon, France

来源：

IMMUNITY | 1998年 / 9卷 / 02期

关键词：

D O I：

10.1016/S1074-7613(00)80610-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus, generated during contact between HIV-infected cells and the apical surface of an epithelial cell, can cross a tight epithelial barrier by transcytosis. We show that transcytosis of primary HIV isolates is blocked by dimeric IgA or IgM against HIV envelope proteins. Neutralization occurs intracellularly within the apical recycling endosome, and immune complexes are specifically recycled to the mucosal surface. One epitope involved in neutralization is a conserved sequence of the gp41 HIV envelope protein subunit. Finally, transcytosis also occurs across functional human mucosal tissue in a process inhibited by a serosal internalization of IgM against the HIV envelope protein. These results suggest that induction of mucosal immunity to HIV envelope proteins may impair the transcytotic route of HIV mucosal transmission.

引用

页码：277 / 287

页数：11

共 45 条

[1] EVIDENCE FOR THE SORTING OF ENDOCYTIC VESICLE CONTENTS DURING THE RECEPTOR-MEDIATED TRANSPORT OF IGG ACROSS THE NEWBORN RAT INTESTINE [J].