Prospective Evaluation of Epstein-Barr Virus Reactivation After Stem Cell Transplantation: Association with Monoclonal Gammopathy

被引：19

作者：

Chiusolo, Patrizia ^{[4
]}

Metafuni, Elisabetta ^{[4
]}

Cattani, Paola ^{[2
]}

Piccirillo, Nicola ^{[4
]}

Santangelo, Rosaria ^{[2
]}

Manzara, Stefania ^{[2
]}

Bellesi, Silvia ^{[4
]}

De Michele, Teresa ^{[3
]}

Leone, Giuseppe ^{[4
]}

Sica, Simona ^{[1
,4
]}

机构：

[1] Policlin Agostino Gemelli, Ist Ematol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Inst Microbiol, Rome, Italy

[3] Inst Biochem & Clin Biochem, Rome, Italy

[4] Inst Haematol, Rome, Italy

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2010年 / 30卷 / 06期

关键词：

EBV; stem cell transplantation; monoclonal gammopathy; PTLD; SERUM-PROTEIN ELECTROPHORESIS; LYMPHOPROLIFERATIVE DISEASE; PERIPHERAL-BLOOD; DISORDER; THERAPY; ORIGIN; PTLD; SCT;

D O I：

10.1007/s10875-010-9454-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Epstein Barr Virus (EBV) reactivation and EBV-related post-transplant lymphoproliferative disease (PTLD) have emerged as a severe complication after stem cell transplantation (SCT). We prospectively evaluated 104 consecutive patients receiving SCT either autologous or allogeneic. Fifty-two patients (50%) presented EBV DNA-emia and five of them developed PTLD proven or probable. PTLD rate was 9.6% among patients with EBV DNA-emia. One patient developed PTLD without EBV DNA-emia (0.96%). Overall PTLD incidence was 5.7%. No PTLD developed after autologous SCT. EBV DNA-emia was significantly more frequent after allogeneic than autologous SCT (60.7% vs 17.4%, p=0.0002). At EBV reactivation, serum protein electrophoresis and immunofixation were assessed. Global incidence of gamma-peak after allogeneic SCT with EBV reactivation was 65.3% (32/49 patients) and monoclonal gammopathy (MG) was identified in 23/28 evaluable patients (82%). All patients with PTLD developed gamma-peak and in five of them MG was identified. MG is consistently associated with EBV DNA-emia and may help identification of progression to PTLD after allogeneic SCT.

引用

页码：894 / 902

页数：9

共 24 条

[1] Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma [J].