Autophagy in the Immunosuppressive Perivascular Microenvironment of Glioblastoma

被引:23
作者
Molina, Maria L. [1 ,2 ]
Garcia-Bernal, David [3 ]
Martinez, Salvador [2 ]
Valdor, Rut [1 ,3 ]
机构
[1] Biomed Res Inst Murcia IMIB Arrixaca, Brain Regionalizat & Dev Gene Unit, Murcia 30120, Spain
[2] UMH, CIBERSAM, ISCIII, Inst Neurociencias,CSIC, Alacant 03550, Spain
[3] Univ Murcia, Dept Internal Med, Biomed Res Inst Murcia IMIBArrixaca, Murcia 30120, Spain
关键词
autophagy; chaperone-mediated autophagy; tumor; glioblastoma; perivascular cells; pericytes; immunosuppressive; tumor immune tolerance; autophagy inhibitors; CHAPERONE-MEDIATED AUTOPHAGY; CLASS-II PRESENTATION; REGULATORY T-CELLS; TUMOR-SUPPRESSOR; MACROPHAGE AUTOPHAGY; OXIDATIVE STRESS; B-CELLS; CANCER; DEGRADATION; ACTIVATION;
D O I
10.3390/cancers12010102
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Glioblastoma (GB) has been shown to up-regulate autophagy with anti- or pro-oncogenic effects. Recently, our group has shown how GB cells aberrantly up-regulate chaperone-mediated autophagy (CMA) in pericytes of peritumoral areas to modulate their immune function through cell-cell interaction and in the tumor's own benefit. Thus, to understand GB progression, the effect that GB cells could have on autophagy of immune cells that surround the tumor needs to be deeply explored. In this review, we summarize all the latest evidence of several molecular and cellular immunosuppressive mechanisms in the perivascular tumor microenvironment. This immunosuppression has been reported to facilitate GB progression and may be differently modulated by several types of autophagy as a critical point to be considered for therapeutic interventions.
引用
收藏
页数:20
相关论文
共 169 条
[121]   Immunotherapy advances for glioblastoma [J].
Reardon, David A. ;
Freeman, Gordon ;
Wu, Catherine ;
Chiocca, E. Antonio ;
Wucherpfennig, Kai W. ;
Wen, Patrick Y. ;
Fritsch, Edward F. ;
Curry, William T., Jr. ;
Sampson, John H. ;
Dranoff, Glenn .
NEURO-ONCOLOGY, 2014, 16 (11) :1441-1458
[122]   Understanding the role of PD-LI/PD I pathway blockade and autophagy in cancer therapy [J].
Robainas, Marianela ;
Otano, Rafael ;
Bueno, Stephen ;
Ait-Oudhia, Sihem .
ONCOTARGETS AND THERAPY, 2017, 10 :1803-1807
[123]   Balance between autophagic pathways preserves retinal homeostasis [J].
Rodriguez-Muela, Natalia ;
Koga, Hiroshi ;
Garcia-Ledo, Lucia ;
de la Villa, Pedro ;
de la Rosa, Enrique J. ;
Cuervo, Ana Maria ;
Boya, Patricia .
AGING CELL, 2013, 12 (03) :478-488
[124]   Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy [J].
Rogov, Vladimir ;
Doetsch, Volker ;
Johansen, Terje ;
Kirkin, Vladimir .
MOLECULAR CELL, 2014, 53 (02) :167-178
[125]   Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive [J].
Rojas-Sanchez, Guadalupe ;
Cotzomi-Ortega, Israel ;
Pazos-Salazar, Nidia G. ;
Reyes-Leyva, Julio ;
Maycotte, Paola .
BIOLOGY-BASEL, 2019, 8 (04)
[126]   A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme [J].
Rosenfeld, Myrna R. ;
Ye, Xiaobu ;
Supko, Jeffrey G. ;
Desideri, Serena ;
Grossman, Stuart A. ;
Brem, Steven ;
Mikkelson, Tom ;
Wang, Daniel ;
Chang, Yunyoung C. ;
Hu, Janice ;
McAfee, Quentin ;
Fisher, Joy ;
Troxel, Andrea ;
Piao, Shengfu ;
Heitjan, Daniel F. ;
Tan, Kay See ;
Pontiggia, Laura ;
O'Dwyer, Peter J. ;
Davis, Lisa E. ;
Amaravadi, Ravi K. .
AUTOPHAGY, 2014, 10 (08) :1359-1368
[127]   Potential therapeutic applications of autophagy [J].
Rubinsztein, David C. ;
Gestwicki, Jason E. ;
Murphy, Leon O. ;
Klionsky, Daniel J. .
NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (04) :304-312
[128]   Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade [J].
Saha, Dipongkor ;
Martuza, Robert L. ;
Rabkin, Samuel D. .
CANCER CELL, 2017, 32 (02) :253-+
[129]   LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy [J].
Saha, Tapas .
AUTOPHAGY, 2012, 8 (11) :1643-1656
[130]   Microautophagy of Cytosolic Proteins by Late Endosomes [J].
Sahu, Ranjit ;
Kaushik, Susmita ;
Clement, Cristina C. ;
Cannizzo, Elvira S. ;
Scharf, Brian ;
Follenzi, Antonia ;
Potolicchio, Ilaria ;
Nieves, Edward ;
Cuervo, Ana Maria ;
Santambrogio, Laura .
DEVELOPMENTAL CELL, 2011, 20 (01) :131-139