Endothelial Dysfunction and Coronary Artery Disease A State of the Art Review

被引：32
作者：
Veerasamy, Murugapathy [1 ,2 ]
Bagnall, Alan [1 ,2 ]
Neely, Dermot [3 ]
Allen, John [1 ,4 ]
Sinclair, Hannah [1 ,2 ]
Kunadian, Vijay [1 ,2 ]
机构：
[1] Newcastle Univ, Fac Med Sci, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[2] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Ctr Cardiothorac, Newcastle Upon Tyne, Tyne & Wear, England
[3] Newcastle Upon Tyne Hosp NHS Fdn Trust, Dept Biochem, Newcastle Upon Tyne, Tyne & Wear, England
[4] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Dept Reg Med Phys, Newcastle Upon Tyne, Tyne & Wear, England
来源：
CARDIOLOGY IN REVIEW | 2015年 / 23卷 / 03期
关键词：
endothelial dysfunction; coronary artery disease; atherosclerosis; FLOW-MEDIATED DILATION; NITRIC-OXIDE SYNTHASE; CONVERTING ENZYME-INHIBITION; INCIDENT CARDIOVASCULAR EVENTS; DEPENDENT DIABETES-MELLITUS; LASER-DOPPLER FLOWMETRY; VASCULAR FUNCTION; BLOOD-FLOW; SHEAR-STRESS; REACTIVE HYPEREMIA;
D O I：
10.1097/CRD.0000000000000047
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atherosclerotic coronary artery disease (CAD) is a major cause of morbidity and mortality in the developed world. Endothelial dysfunction plays an important role in the development of atherosclerosis and predicts cardiovascular (CV) outcomes independent of conventional CV risk factors. In recent years, there have been tremendous improvements in the pharmacological prevention and management of CAD. In this review, the pathophysiology of endothelial dysfunction in relation to CAD is discussed and various techniques of invasive and noninvasive assessments of peripheral and coronary endothelial function described. In addition, evidence for the association of endothelial dysfunction and CV outcomes has been examined and finally the role of therapeutic interventions in endothelial dysfunction has been discussed.
引用
收藏
页码：119 / 129
页数：11
相关论文
共 50 条
  • [41] Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease
    Sancheti, Saurabh
    Shah, Prasad
    Phalgune, Deepak S.
    INDIAN HEART JOURNAL, 2018, 70 (05) : 622 - 626
  • [42] Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction
    Isra Marei
    Omar Chidiac
    Binitha Thomas
    Jennifer Pasquier
    Soha Dargham
    Amal Robay
    Muneera Vakayil
    Mohammad Jameesh
    Christopher Triggle
    Arash Rafii
    Amin Jayyousi
    Jassim Al Suwaidi
    Charbel Abi Khalil
    Cardiovascular Diabetology, 21
  • [43] Comparison of peripheral endothelial dysfunction and intimal media thickness in patients with suspected coronary artery disease
    Enderle, MD
    Schroeder, S
    Ossen, R
    Meisner, C
    Baumbach, A
    Haering, HU
    Karsch, KR
    Pfohl, M
    HEART, 1998, 80 (04) : 349 - 354
  • [44] Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction
    Marei, Isra
    Chidiac, Omar
    Thomas, Binitha
    Pasquier, Jennifer
    Dargham, Soha
    Robay, Amal
    Vakayil, Muneera
    Jameesh, Mohammad
    Triggle, Christopher
    Rafii, Arash
    Jayyousi, Amin
    Al Suwaidi, Jassim
    Khalil, Charbel Abi
    CARDIOVASCULAR DIABETOLOGY, 2022, 21 (01)
  • [45] Relationship between endothelial dysfunction and cardiovascular risk factors and the extent and severity of coronary artery disease
    Gumusel, Hilal Kurtoglu
    Catakoglu, Alp Burak
    Yildirimturk, Ozlem
    Yurdakul, Selen
    Helvacioglu, Funda
    Ziyrek, Murat
    Hanavdelogullari, Ruken
    Aytekin, Vedat
    Aytekin, Saide
    TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, 2014, 42 (05): : 435 - 443
  • [46] Remnant lipoproteinemia is a risk factor for endothelial vasomotor dysfunction and coronary artery disease in metabolic syndrome
    Nakamura, T
    Takano, H
    Umetani, K
    Kawabata, K
    Obata, JE
    Kitta, Y
    Kodama, Y
    Mende, A
    Ichigi, Y
    Fujioka, D
    Saito, Y
    Kugiyama, K
    ATHEROSCLEROSIS, 2005, 181 (02) : 321 - 327
  • [47] Screening for Coronary Artery Disease in Cancer Survivors JACC: CardioOncology State-of-the-Art Review
    Velusamy, Ragani
    Nolan, Mark
    Murphy, Andrew
    Thavendiranathan, Paaladinesh
    Marwick, Thomas H.
    JACC: CARDIOONCOLOGY, 2023, 5 (01): : 22 - 38
  • [48] Coronary Artery Disease and Transcatheter Aortic Valve Replacement JACC State-of-the-Art Review
    Faroux, Laurent
    Guimaraes, Leonardo
    Wintzer-Wehekind, Jerome
    Junquera, Lucia
    Ferreira-Neto, Alfredo Nunes
    del Val, David
    Muntane-Carol, Guillem
    Mohammadi, Siamak
    Paradis, Jean-Michel
    Rodes-Cabau, Josep
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 74 (03) : 362 - 372
  • [49] Erectile dysfunction in patients with coronary artery disease
    Kloner, R
    Padma-Nathan, H
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2005, 17 (03) : 209 - 215
  • [50] Erectile dysfunction in patients with coronary artery disease
    R Kloner
    H Padma-Nathan
    International Journal of Impotence Research, 2005, 17 : 209 - 215
12345