Endothelial Dysfunction and Coronary Artery Disease A State of the Art Review

被引：32
作者：
Veerasamy, Murugapathy [1 ,2 ]
Bagnall, Alan [1 ,2 ]
Neely, Dermot [3 ]
Allen, John [1 ,4 ]
Sinclair, Hannah [1 ,2 ]
Kunadian, Vijay [1 ,2 ]
机构：
[1] Newcastle Univ, Fac Med Sci, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[2] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Ctr Cardiothorac, Newcastle Upon Tyne, Tyne & Wear, England
[3] Newcastle Upon Tyne Hosp NHS Fdn Trust, Dept Biochem, Newcastle Upon Tyne, Tyne & Wear, England
[4] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Dept Reg Med Phys, Newcastle Upon Tyne, Tyne & Wear, England
来源：
CARDIOLOGY IN REVIEW | 2015年 / 23卷 / 03期
关键词：
endothelial dysfunction; coronary artery disease; atherosclerosis; FLOW-MEDIATED DILATION; NITRIC-OXIDE SYNTHASE; CONVERTING ENZYME-INHIBITION; INCIDENT CARDIOVASCULAR EVENTS; DEPENDENT DIABETES-MELLITUS; LASER-DOPPLER FLOWMETRY; VASCULAR FUNCTION; BLOOD-FLOW; SHEAR-STRESS; REACTIVE HYPEREMIA;
D O I：
10.1097/CRD.0000000000000047
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atherosclerotic coronary artery disease (CAD) is a major cause of morbidity and mortality in the developed world. Endothelial dysfunction plays an important role in the development of atherosclerosis and predicts cardiovascular (CV) outcomes independent of conventional CV risk factors. In recent years, there have been tremendous improvements in the pharmacological prevention and management of CAD. In this review, the pathophysiology of endothelial dysfunction in relation to CAD is discussed and various techniques of invasive and noninvasive assessments of peripheral and coronary endothelial function described. In addition, evidence for the association of endothelial dysfunction and CV outcomes has been examined and finally the role of therapeutic interventions in endothelial dysfunction has been discussed.
引用
收藏
页码：119 / 129
页数：11
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