The Comparative Toxicogenomics Database: update 2011

被引：196

作者：

Davis, Allan Peter ^{[1
]}

King, Benjamin L. ^{[1
]}

Mockus, Susan ^{[1
]}

Murphy, Cynthia G. ^{[1
]}

Saraceni-Richards, Cynthia ^{[1
]}

Rosenstein, Michael ^{[1
]}

Wiegers, Thomas ^{[1
]}

Mattingly, Carolyn J. ^{[1
]}

机构：

[1] Mt Desert Isl Biol Lab, Dept Bioinformat, Salsbury Cove, ME 04672 USA

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

基金：

美国国家卫生研究院;

关键词：

ENVIRONMENTAL-HEALTH; TOOL; KNOWLEDGEBASE; CHEMICALS; RESOURCE; CTD;

D O I：

10.1093/nar/gkq813

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Comparative Toxicogenomics Database (CTD) is a public resource that promotes understanding about the interaction of environmental chemicals with gene products, and their effects on human health. Biocurators at CTD manually curate a triad of chemical-gene, chemical-disease and gene-disease relationships from the literature. These core data are then integrated to construct chemical-gene-disease networks and to predict many novel relationships using different types of associated data. Since 2009, we dramatically increased the content of CTD to 1.4 million chemical-gene-disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps (to find comparable genes and chemicals that share toxicogenomic profiles), enriched Gene Ontology terms associated with chemicals, statistically ranked chemical-disease inferences, Venn diagram tools to discover overlapping and unique attributes of any set of chemicals, genes or disease, and enhanced gene pathway data content, among other features. Together, this wealth of expanded chemical-gene-disease data continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. CTD is freely available at http://ctd.mdibl.org.

引用

页码：D1067 / D1072

页数：6

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