Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells

被引：19
|
作者：
Kutsukake, Masahiko [1 ]
Ishihara, Ryosuke [1 ]
Yoshie, Mikihiro [1 ]
Kogo, Hiroshi [1 ]
Tamura, Kazuhiro [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Dept Endocrine Pharmacol, Tokyo 1920392, Japan
来源：
MOLECULAR HUMAN REPRODUCTION | 2007年 / 13卷 / 10期
基金：
日本学术振兴会;
关键词：
IGFBP-rP1; uterus; decidualization; endometrial stromal cells;
D O I：
10.1093/molehr/gam058
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Uterine decidualization is crucial for successful implantation and the establishment of pregnancy. In the present study, the expression of insulin-like growth factor-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) in the human uterus and endometrial stromal cells (ESCs) and its physiological significance in decidualization were examined. IGFBP-rP1 protein was localized in the glandular epithelium and stromal cells, and blood vessels in the endometrium. Cultured stromal cells expressed IGFBP-rP1 and secreted it into the medium. IGFBP-rP1 was localized mostly in the cytoplasm near the nucleus. Knocking down the endogenous IGFBP-rP1 expression in stromal cells, by a small interfering (si)RNA, diminished the expression of prolactin and IGFBP-1 which serve as decidual markers. These results suggest that IGFBP-rP1 may play a role in decidualization of ESCs.
引用
收藏
页码：737 / 743
页数：7
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