Nucleus deformation of SaOs-2 cells on rhombic μ-pillars

被引：10
作者：
Eichhorn, Melanie [1 ]
Stannard, Cleo [1 ,2 ]
Anselme, Karine [3 ]
Ruehe, Juergen [1 ]
机构：
[1] Univ Freiburg, Dept Microsyst Engn, Lab Chem & Phys Interfaces, D-79106 Freiburg, Germany
[2] Harvey Mudd Coll, Claremont, CA 91711 USA
[3] Univ Haute Alsace, CNRS UMR7361, Inst Sci Mat Mulhouse, Mulhouse, France
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2015年 / 26卷 / 02期
关键词：
CYTOSKELETON ORGANIZATION; CANCER-CELLS; SURFACES; GEOMETRY; FORCE;
D O I：
10.1007/s10856-015-5427-1
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
It has been previously shown that osteosarcoma (SaOs-2) cells respond to micropillared surfaces consisting of poly-L-lactic acid with strong deformation of the cell body and nucleus. Until now, cell nucleus deformation of SaOs-2 cells was only studied by exposing them to square shaped micropillars in an isotropic pattern. Herewe report on experiments of the cell nucleus response of such cells to rhombic structures of different topographies generated from a rubbery polymer, namely poly(n-butyacrylate). It is observed that cells orientate themselves perpendicular to the long axis of the rhombi. While their spreading on the surface is not influenced by the opening angle of the structures, rhombic structures with sharper angles induce stronger deformation of the cells and accordingly more elongated nuclei.
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页码：1 / 6
页数：6
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