Broad spectrum anti-microbial compounds producing bacteria from coast of Qingdao bays

被引：0

作者：

Khan, Muhammad Naseem ^{[1
,2
]}

Li, Meng ^{[1
]}

Mirani, Zulfiqar Ali ^{[2
]}

Wang, Jingxue ^{[1
]}

Lin, Hong ^{[1
]}

Buzdar, Muhammad Aslam ^{[3
]}

机构：

[1] Ocean Univ China, Coll Food Sci & Engn, Food Safety Lab, Qingdao, Peoples R China

[2] FMRRC, Microbiol Analyt Ctr, PCSIR Labs, Karachi, Pakistan

[3] Lasbela Univ Agr Water & Marine Sci, Fac Marine Sci, Uthal, Pakistan

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2015年 / 28卷 / 02期

关键词：

Broad spectrum; marine bacteria; anti-microbial; MRSA; Bacillus sp; Vibrio sp; ANTIBIOTIC-RESISTANCE; MARINE-BACTERIA; PURIFICATION; METABOLITES; INFECTIONS; PROTEIN;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Anti-microbial resistance burden and hazard associated with chemical treatment of infections demanded for new anti-microbial natural products. Marine associated microorganisms are the enormous source of bioactive compounds. In this study we have isolated 272 marine bacteria among them 136 (50%) were antagonistic to at least one of the four pathogenic strains Listeria monocytogenes, Vibrio cholerae, E. coli and S. aureus. Only two strains exhibited antibacterial activity against all four test strains, which were identified by 16S rDNA sequencing as Bacillus sp. DK1-SA1 1 and Vibrio sp. DK6-SH8. Marine isolate DK1-SA11 has potential to resist boiling temperature and pH 2-12. Furthermore cell free extract (CFE) inhibited all test organisms including superbug MRSA and pathogenic yeast Candida albicans. Marine isolate Bacillus sp. DK1-SA11 could be a potential combatant for the battle of drugs and bugs.

引用

页码：473 / 482

页数：10

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