Spatial reference memory in normal aging Fischer 344 x Brown Norway F1 hybrid rats

被引:25
作者
McQuail, Joseph A. [1 ]
Nicolle, Michelle M. [1 ,2 ,3 ]
机构
[1] Wake Forest Univ, Program Neurosci, Grad Sch, Winston Salem, NC 27109 USA
[2] Wake Forest Univ, Sch Med, Sect Gerontol, Dept Internal Med, Winston Salem, NC 27109 USA
[3] Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27109 USA
基金
美国国家卫生研究院;
关键词
Normal aging; Hybrid rat; Hippocampus; Spatial reference memory; Individual differences; Working memory; Retention; Procedural learning; CAUDATE-PUTAMEN LESIONS; MORRIS WATER TASK; PLACE NAVIGATION; WORKING-MEMORY; COGNITIVE IMPAIRMENT; LEARNING IMPAIRMENT; DORSAL STRIATUM; ANIMAL-MODELS; HIPPOCAMPAL; RESTRICTION;
D O I
10.1016/j.neurobiolaging.2014.06.030
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Fischer 344 x Brown Norway F1 (F344 x BN-F1) hybrid rats express greater longevity with improved health relative to aging rodents of other strains; however, few behavioral reports have thoroughly evaluated cognition across the F344 x BN-F1 lifespan. Consequently, this study evaluated spatial reference memory in F344 x BN-F1 rats at 6, 18, 24, or 28 months of age in the Morris water maze. Reference memory decrements were observed between 6 and 18 months and 18 and 24 months. At 28 months, spatial learning was not worse than 24 months, but swim speed was significantly slower. Reliable individual differences revealed that similar to 50% of 24-to 28-month-old rats performed similarly to 6 months, whereas others were spatial learning impaired. Aged rats were impaired at learning within daily training sessions but not impaired at retaining information between days of training. Aged rats were also slower to learn to escape onto the platform, regardless of strategy. In summary, these data clarify the trajectory of cognitive decline in aging F344 x BN-F1 rats and elucidate relevant behavioral parameters. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:323 / 333
页数:11
相关论文
共 58 条
  • [1] Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability
    Adams, Michelle M.
    Shi, Lei
    Linville, M. Constance
    Forbes, M. Elizabeth
    Long, Ashley B.
    Bennett, Colleen
    Newton, Isabel G.
    Carter, Christy S.
    Sonntag, William E.
    Riddle, David R.
    Brunso-Bechtold, Judy K.
    [J]. EXPERIMENTAL NEUROLOGY, 2008, 211 (01) : 141 - 149
  • [2] Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
    Ahlskog, J. Eric
    Geda, Yonas E.
    Graff-Radford, Neill R.
    Petersen, Ronald C.
    [J]. MAYO CLINIC PROCEEDINGS, 2011, 86 (09) : 876 - 884
  • [3] SPATIAL MEMORY DEFICIT IN SENESCENT RATS
    BARNES, CA
    NADEL, L
    HONIG, WK
    [J]. CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE, 1980, 34 (01): : 29 - 39
  • [4] Multistability of cognitive maps in the hippocampus of old rats
    Barnes, CA
    Suster, MS
    Shen, JM
    McNaughton, BL
    [J]. NATURE, 1997, 388 (6639) : 272 - 275
  • [5] Neurobiological substrates of behavioral decline: Models and data analytic strategies for individual differences in aging
    Baxter, MG
    Gallagher, M
    [J]. NEUROBIOLOGY OF AGING, 1996, 17 (03) : 491 - 495
  • [6] Diabetes and cognitive impairment - Clinical diagnosis and brain imaging in patients attending a memory clinic
    Biessels, GJ
    Koffeman, A
    Scheltens, P
    [J]. JOURNAL OF NEUROLOGY, 2006, 253 (04) : 477 - 482
  • [7] Spatial reference and working memory across the lifespan of male Fischer 344 rats
    Bizon, J. L.
    LaSarge, C. L.
    Montgomery, K. S.
    McDermott, A. N.
    Setlow, B.
    Griffith, W. H.
    [J]. NEUROBIOLOGY OF AGING, 2009, 30 (04) : 646 - 655
  • [8] Characterizing cognitive aging of working memory and executive function in animal models
    Bizon, Jennifer L.
    Foster, Thomas C.
    Alexander, Gene E.
    Glisky, Elizabeth L.
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2012, 4
  • [9] Pattern Separation Deficits May Contribute to Age-Associated Recognition Impairments
    Burke, Sara N.
    Wallace, Jenelle L.
    Nematollahi, Saman
    Uprety, Ajay R.
    Barnes, Carol A.
    [J]. BEHAVIORAL NEUROSCIENCE, 2010, 124 (05) : 559 - 573
  • [10] Influence of Calorie Restriction on Measures of Age-Related Cognitive Decline: Role of Increased Physical Activity
    Carter, Christy S.
    Leeuwenburgh, Christiaan
    Daniels, Michael
    Foster, Thomas C.
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2009, 64 (08): : 850 - 859