Effects of Sanyaku and Its Constituent Diosgenin on the Fasted and Postprandial Hypertriacylglycerolemia in High-Fat-Diet-Fed KK-AY Mice

被引:31
作者
Hashidume, Tsutomu [1 ,2 ]
Sasaki, Kaori [1 ]
Hirata, Jun [1 ]
Kato, Mai [2 ]
Yoshikawa, Yuko [1 ,3 ]
Iwasaki, Yusaku [4 ]
Arai, Hidekazu [1 ,2 ]
Miura, Shinji [1 ,2 ]
Miyoshi, Noriyuki [1 ,2 ]
机构
[1] Univ Shizuoka, Grad Sch Integrated Pharmaceut & Nutr Sci, Shizuoka 4228526, Japan
[2] Univ Shizuoka, Sch Food Nutr Sci, Shizuoka 4228526, Japan
[3] Nippon Vet & Life Sci Univ, Fac Vet Sci, Sch Vet Med, Tokyo 1800023, Japan
[4] Kyoto Prefectural Univ, Grad Sch Life & Environm Sci, Lab Anim Sci, Sakyo Ku, 1-5 Hangi Cho, Kyoto 6068522, Japan
基金
日本学术振兴会;
关键词
diosgenin; hypertriacylglycerolemia; oral fat tolerance test; lipoprotein lipase; LYMPHATIC TRANSPORT; DIABETES-MELLITUS; VISCERAL OBESITY; RATS; HYPERTRIGLYCERIDEMIA; METABOLISM; KINETICS; ALPHA; MASS;
D O I
10.1021/acs.jafc.8b03040
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
In this study, we examined the fasted and postprandial triacylglycerol (TG) levels in ICK-A(Y) mice fed a high-fat diet (HFD) or a HFD containing either 500 ppm (0.05%) of diosgenin or 500 ppm (0.05%) of diosgenin-containing Chinese yam sanyaku. Oral fat tolerance tests revealed that, not only in the fasting state but also after loading of lipid emulsion, plasma levels of TG were significantly reduced in sanyaku- and diosgenin- fed mice. Levels of fat oxidation, especially in the dark phase (from 7 p.m. to 7 a.m.), were increased in the sanyaku and diosgenin groups. Moreover mRNA levels of lipoprotein lipase and peroxisome proliferator-activated receptor gamma, coactivator l alpha were moderately upregulated in the liver of sanyaku- and diosgenin-ingested mice. These results suggest that consecutive ingestion of diosgenin or diosgenin-containing sanyaku at the dose achievable in a human diet potentially ameliorates fasted and postprandial hypertriacylglycerolemia, which could be associated with the improvement of TG metabolism.
引用
收藏
页码:9968 / 9975
页数:8
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