Protein folding: A missing redox link in the endoplasmic reticulum

被引:31
作者
Freedman, RB [1 ]
Dunn, AD [1 ]
Ruddock, LW [1 ]
机构
[1] Univ Kent, Res Sch Biosci, Canterbury CT2 7NJ, Kent, England
关键词
D O I
10.1016/S0960-9822(98)70295-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Native disulphide-bond formation duping protein folding in the endoplasmic reticulum requires oxidative machinery, the components and mechanism of which are not yet fully understood. Two recent papers have identified a novel protein component that appears to play a key rose In this important redox pathway. (C) Current Biology Ltd.
引用
收藏
页码:R468 / R470
页数:3
相关论文
共 9 条
[1]   ON THE BIOSYNTHESIS OF BOVINE PANCREATIC TRYPSIN-INHIBITOR (BPTI) - STRUCTURE, PROCESSING, FOLDING AND DISULFIDE BOND FORMATION OF THE PRECURSOR IN-VITRO AND IN MICROSOMES [J].
CREIGHTON, TE ;
BAGLEY, CJ ;
COOPER, L ;
DARBY, NJ ;
FREEDMAN, RB ;
KEMMINK, J ;
SHEIKH, A .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 232 (04) :1176-1196
[2]   The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum [J].
Frand, AR ;
Kaiser, CA .
MOLECULAR CELL, 1998, 1 (02) :161-170
[3]   THE FORMATION OF PROTEIN DISULFIDE BONDS [J].
FREEDMAN, RB .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1995, 5 (01) :85-91
[4]   PDI AND GLUTATHIONE-MEDIATED REDUCTION OF THE GLUTATHIONYLATED VARIANT OF HUMAN LYSOZYME [J].
HAYANO, T ;
INAKA, K ;
OTSU, M ;
TANIYAMA, Y ;
MIKI, K ;
MATSUSHIMA, M ;
KIKUCHI, M .
FEBS LETTERS, 1993, 328 (1-2) :203-208
[5]   OXIDIZED REDOX STATE OF GLUTATHIONE IN THE ENDOPLASMIC-RETICULUM [J].
HWANG, C ;
SINSKEY, AJ ;
LODISH, HF .
SCIENCE, 1992, 257 (5076) :1496-1502
[6]  
MARQUARDT T, 1993, J BIOL CHEM, V268, P19618
[7]   Ero1p: A novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum [J].
Pollard, MG ;
Travers, KJ ;
Weissman, JS .
MOLECULAR CELL, 1998, 1 (02) :171-182
[8]   STIMULATION OF THE DITHIOL-DEPENDENT REDUCTASES IN THE VITAMIN-K CYCLE BY THE THIOREDOXIN SYSTEM - STRONG SYNERGISTIC EFFECTS WITH PROTEIN DISULFIDE-ISOMERASE [J].
SOUTE, BAM ;
GROENENVANDOOREN, MMCL ;
HOLMGREN, A ;
LUNDSTROM, J ;
VERMEER, C .
BIOCHEMICAL JOURNAL, 1992, 281 :255-259
[9]   PROTEIN DISULFIDE BOND SYNTHESIS - POSSIBLE INTRACELLULAR MECHANISM [J].
ZIEGLER, DM ;
POULSEN, LL .
TRENDS IN BIOCHEMICAL SCIENCES, 1977, 2 (04) :79-81