GALECTIN-1 AND HIV-1 INFECTION

被引：30

作者：

St-Pierre, Christian ^{[1
]}

Ouellet, Michel ^{[2
]}

Tremblay, Michel J. ^{[2
]}

Sato, Sachiko ^{[1
]}

机构：

[1] Univ Laval, Fac Med, Res Ctr Infect Dis, Glycobiol & Bioimaging Lab, Quebec City, PQ G1K 7P4, Canada

[2] Univ Laval, Fac Med, Res Ctr Infect Dis, Lab Human Immunoretrovirol, Quebec City, PQ G1K 7P4, Canada

来源：

METHODS IN ENZYMOLOGY, VOL 480: GLYCOBIOLOGY | 2010年 / 480卷

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; GALACTOSIDE-BINDING LECTINS; ACTIVATED RAT MACROPHAGES; SITE-DIRECTED MUTAGENESIS; CD4(+) T-LYMPHOCYTES; NF-KAPPA-B; DC-SIGN; REGULATED EXPRESSION; MAMMALIAN-CELLS; NEUTRALIZING ANTIBODIES;

D O I：

10.1016/S0076-6879(10)80013-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Initial binding of human immunodeficiency virus-1 (HIV-1) to its susceptible CD4(+) cells is the limiting step for the establishment of infection as the avidity of viral envelope gp120 for CD4 is not high and the number of viral envelope spikes on the surface is found to be low compared to highly infectious viruses. Several host factors, such as C-type lectins, are listed as being able to enforce or facilitate the crucial interaction of HIV-1 to the susceptible cell. Recent works suggest that a host soluble beta-galactoside-binding lectin, galectin-1, also facilitates both virion binding and the infection of target cells in a manner dependent on lactose but not mannose, suggesting that this soluble galectin can be considered as a host factor that influences HIV-1 pathogenesis. In this chapter, we describe methods used to investigate the potential role of the galectin family in HIV-1-mediated disease progression.

引用

页码：267 / 294

页数：28

共 105 条

[21] Characterization of monomeric forms of galectin-1 generated by site-directed mutagenesis [J].