In non-follicular lymphoproliferative disorders, IGH/BCL2-fusion is not restricted to chronic lymphocytic leukaemia

被引：25

作者：

Baseggio, Lucile ^{[5
]}

Geay, Marie-Odile ^{[5
]}

Gazzo, Sophie ^{[5
]}

Berger, Francoise ^{[2
,5
]}

Traverse-Glehen, Alexandra ^{[2
,5
]}

Ffrench, Martine ^{[5
]}

Hayette, Sandrine ^{[5
]}

Callet-Bauchu, Evelyne ^{[5
]}

Verney, Aurelie ^{[5
]}

Morel, Dominique ^{[5
]}

Jallades, Laurent ^{[5
]}

Magaud, Jean-Pierre ^{[5
]}

Salles, Gilles ^{[3
,4
,5
]}

Felman, Pascale ^{[1
,5
]}

机构：

[1] Ctr Hosp Lyon Sud, Lab Hematol Cellulaire, Serv Hematol Biol, F-69495 Pierre Benite, France

[2] Ctr Hosp Lyon Sud, Serv Anat Pathol, F-69495 Pierre Benite, France

[3] Ctr Hosp Lyon Sud, Serv Hematol Clin, F-69495 Pierre Benite, France

[4] Univ Lyon 1, Hosp Civils Lyon, F-69365 Lyon, France

[5] Univ Lyon 1, Pathol Cellules Lymphoides UMR5239, F-69365 Lyon, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2012年 / 158卷 / 04期

关键词：

chronic lymphocytic leukaemia; t(14; 18); marginal zone lymphoma; immunophenotype; IGHV; FISH; MARGINAL ZONE LYMPHOMAS; B-CELL LYMPHOMA; SOMATIC HYPERMUTATION; BCL-6; MUTATIONS; TRISOMY-12; GENES; T(14/18)(Q32; Q21); TRANSLOCATION; ASSOCIATION; DIAGNOSIS;

D O I：

10.1111/j.1365-2141.2012.09178.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The translocation t(14;18) and its t(2;18) and t(18,22) variants, which involve the BCL2 genetic hallmark for follicular lymphoma (FL), have been reported in several cases of chronic B-cell lymphoproliferative disease (CLPD) and frequently in chronic lymphocytic leukaemia (CLL). We describe here the clinical, morphological, immunological, cytogenetic and molecular findings from 37 cases of t(14;18)-positive CLPD, identified from our series of non-FL B-cell neoplasms (n similar to 993) that were routinely analysed in peripheral blood by conventional cytogenetics analyses. The FL diagnosis was excluded by morphology and immunology (the samples were CD10 negative in all cases). The BCL2 translocations were observed in 22 CLL cases, including 7 monoclonal B-cell lymphocytosis (MBL) cases re-classified according to the new International Workshop on CLL criteria, six small lymphocytic lymphoma (SLL) cases, 1 splenic marginal zone lymphoma (SMZL) case and eight cases of unclassifiable CLPD with overlapping CLL/MZL features. In the CLL cases, the IGH/BCL2 fusion was remarkably associated with trisomy 12 (13/22) and mutated IGHV status (20/21) and did not affect the outcome. Moreover, most of these CLLs harboured a low mutation load of BCL6 gene and unmutated FAS (CD95) loci, which points to a postgerminal-centre cellular origin.

引用

页码：489 / 498

页数：10

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