Antibacterial coating with antibiotics is highly effective in avoiding device-associated infections (DAIs) which is an unsolved healthcare problem that causes significant morbidity and mortality rates. However, bacterial drug resistance caused by uncontrolled release of antibiotics seriously restricts clinical efficacy of antibacterial coating. Hence, a local and controlled-release system which can release antibiotics in response to bacterial infected signals is necessary in antibacterial coating. Herein, a multi-stimulus responsive multilayer antibacterial coating was prepared through layer-by-layer (LbL) self-assembly of montmorillonite (MMT), chlorhexidine acetate (CHA) and Poly(protocatechuic acid-polyethylene glycol 1000-bis(phenylboronic acid carbamoyl) cystamine) (PPPB). The coating can be covered on various substrates such as cellulose acetate membrane, polyacrylonitrile membrane, polyvinyl chloride membrane, and polyurethane membrane, proving it is a versatile coating. Under the stimulation of acids, glucose or dithiothreitol, this coating was able to achieve controlled release of CHA and kill more than 99% of Staphylococcus aureus and Escherichia coli (4 x 10(8) CFU/mL) within 4 h. In the mouse infection model, CHA releasing of the coating was triggered by infected microenvironment to completely kill bacteria, achieving wounds healing within 14 days.
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Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Chen, Rui
Shi, Changgui
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Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Shi, Changgui
Xi, Yanhai
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Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Xi, Yanhai
Zhao, Peng
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Tongji Univ, Shanghai East Hosp, Sch Med, Inst Biomed Engn & Nanosci, Shanghai, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Zhao, Peng
He, Hailong
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Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
机构:
Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Chen, Rui
Shi, Changgui
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h-index: 0
机构:
Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Shi, Changgui
Xi, Yanhai
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h-index: 0
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Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Xi, Yanhai
Zhao, Peng
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h-index: 0
机构:
Tongji Univ, Shanghai East Hosp, Sch Med, Inst Biomed Engn & Nanosci, Shanghai, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China
Zhao, Peng
He, Hailong
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h-index: 0
机构:
Second Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Spine Surg Ctr, Dept Orthopaed Surg, Shanghai 200003, Peoples R China