Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections

被引:16
作者
Li, Wenlong [1 ]
Hua, Guanping [1 ]
Cai, Jingfeng [1 ]
Zhou, Yaming [1 ]
Zhou, Xi [1 ]
Wang, Miao [1 ]
Wang, Xiumin [2 ]
Fu, Baoqing [3 ]
Ren, Lei [1 ,4 ]
机构
[1] Xiamen Univ, Coll Mat, Higher Educ Key Lab Biomed Engn Fujian Prov, Res Ctr Biomed Engn Xiamen,Dept Biomat, 422 Siming Nan Rd, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361102, Peoples R China
[3] Xiamen Univ, Sch Med, Xiangan Hosp, Dept Lab Med, Xiamen 361102, Peoples R China
[4] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China
基金
中国国家自然科学基金;
关键词
device-associated infections; multi-stimulus responsiveness; antibacterial coating; wound healing; ANTIBACTERIAL; BIOFILM; RELEASE; MONTMORILLONITE; SURFACE; FILMS;
D O I
10.3390/jfb13010024
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Antibacterial coating with antibiotics is highly effective in avoiding device-associated infections (DAIs) which is an unsolved healthcare problem that causes significant morbidity and mortality rates. However, bacterial drug resistance caused by uncontrolled release of antibiotics seriously restricts clinical efficacy of antibacterial coating. Hence, a local and controlled-release system which can release antibiotics in response to bacterial infected signals is necessary in antibacterial coating. Herein, a multi-stimulus responsive multilayer antibacterial coating was prepared through layer-by-layer (LbL) self-assembly of montmorillonite (MMT), chlorhexidine acetate (CHA) and Poly(protocatechuic acid-polyethylene glycol 1000-bis(phenylboronic acid carbamoyl) cystamine) (PPPB). The coating can be covered on various substrates such as cellulose acetate membrane, polyacrylonitrile membrane, polyvinyl chloride membrane, and polyurethane membrane, proving it is a versatile coating. Under the stimulation of acids, glucose or dithiothreitol, this coating was able to achieve controlled release of CHA and kill more than 99% of Staphylococcus aureus and Escherichia coli (4 x 10(8) CFU/mL) within 4 h. In the mouse infection model, CHA releasing of the coating was triggered by infected microenvironment to completely kill bacteria, achieving wounds healing within 14 days.
引用
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页数:17
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