A comprehensive cytogenetic classification of 1466 Chinese patients with de novo acute lymphoblastic leukemia

被引：11

作者：

Li, Xin ^{[1
]}

Li, Juan ^{[1
]}

Hu, Yanjie ^{[1
]}

Xie, Wei ^{[1
]}

Du, Wen ^{[1
]}

Liu, Wei ^{[1
]}

Li, Xiaoqing ^{[1
]}

Chen, Xiangjun ^{[1
]}

Li, Hongrui ^{[1
]}

Wang, Junfeng ^{[1
]}

Zhang, Lannan ^{[1
]}

Huang, Shiang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Ctr Stem Cell, Union Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Acute lymphoblastic leukemia; Additional cytogenetic abnormalities; Chromosomal abnormalities; Cytogenetic abnormalities; Cytogenetics; Molecular cytogenetics; FUSION GENE TRANSCRIPTS; RESIDUAL-DISEASE; CHILDREN; PROTOCOL; ABNORMALITIES; IMPACT;

D O I：

10.1016/j.leukres.2011.12.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetics and molecular cytogenetics of 1466 Chinese patients with de novo acute lymphoblastic leukemia (ALL) were studied. Cytogenetic results were available in 1175 patients. Cross-correlations of 23 subclasses of cytogenetic abnormalities were described. Childhood cases had higher incidences of normal karyotype, t(1; 19), +8, 12q-, +21, +22 and high hyperdiploidy with 51-65 chromosomes, and lower incidences of t(9; 22) and -5/5q- than adult ones (all p < 0.05). Relationships of cytogenetic subclasses with immunophenotyping subgroups of ALL were studied. Our study presents the cytogenetic characteristics of a large series of Chinese ALL patients. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：720 / 726

页数：7

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