Outcomes of resections for pancreatic adenocarcinoma with suspected venous involvement: a single center experience

被引：10

作者：

Michalski, Christoph W. ^{[1
]}

Kong, Bo ^{[1
]}

Jaeger, Carsten ^{[1
]}

Kloe, Silke ^{[1
]}

Beier, Barbara ^{[1
]}

Braren, Rickmer ^{[2
]}

Esposito, Irene ^{[3
]}

Erkan, Mert ^{[1
]}

Friess, Helmut ^{[1
]}

Kleeff, Jorg ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Surg, D-81675 Munich, Germany

[2] Tech Univ Munich, Inst Radiol, D-81675 Munich, Germany

[3] Tech Univ Munich, Inst Pathol, D-81675 Munich, Germany

来源：

BMC SURGERY | 2015年 / 15卷

关键词：

Pancreatic cancer; Venous invasion; Upfront surgery; Prognosis; PORTAL-VEIN RESECTION; LONG-TERM SURVIVAL; SURGICAL COMPLICATIONS; DUCTAL ADENOCARCINOMA; CANCER; HEAD; PANCREATICODUODENECTOMY; CLASSIFICATION; DEFINITION; SURGERY;

D O I：

10.1186/s12893-015-0086-1

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Pancreatic ductal adenocarcinoma (PDAC) patients frequently present with borderline resectable disease, which can be due to invasion of the portal/superior mesenteric vein (PV/SMV). Here, we analyzed this group of patients, with emphasis on short and long-term outcomes. Methods: 156 patients who underwent a resection for PDAC were included in the analysis and sub-stratified into a cohort of patients with PV/SMV resection (n = 54) versus those with standard surgeries (n = 102). Results: While venous resections could be performed safely, there was a trend towards shorter median survival in the PV/SMV resection group (22.7 vs. 15.8 months, p = 0.157). These tumors were significantly larger (3.5 vs 4.3 cm; p = 0.026) and margin-positivity was more frequent (30.4 % vs 44.4 %, p = 0.046). Conclusion: Venous resection was associated with a higher rate of margin positivity and a trend towards shorter survival. However, compared to non-surgical treatment, resection offers the best chance for long term survival.

引用

页数：8

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