Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas

被引：111

作者：

Ellingson, Benjamin M. ^{[1
]}

Cloughesy, Timothy F. ^{[2
]}

Pope, Whitney B. ^{[1
]}

Zaw, Taryar M. ^{[1
]}

Phillips, Heidi ^{[3
]}

Lalezari, Shadi ^{[2
]}

Nghiemphu, Phioanh L. ^{[2
]}

Ibrahim, Hassana ^{[1
]}

Naeini, Kourosh M. ^{[1
]}

Harris, Robert J. ^{[1
]}

Lai, Albert ^{[2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[3] Genentech Inc, Dept Tumor Biol & Angiogenesis, San Francisco, CA 94080 USA

来源：

NEUROIMAGE | 2012年 / 59卷 / 02期

关键词：

Radiogenomics; MGMT; Glioblastoma; GBM; Tumor location; BRAIN-TUMORS; STEM-CELLS; ASYMMETRY; MULTIFORME; LOCATION; SURVIVAL; GROWTH; EXTENT; VOXEL; MEDULLOBLASTOMAS;

D O I：

10.1016/j.neuroimage.2011.09.076

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Promoter methylation of O6-methylguanine DNA methyltransferase (MGMT) is associated with a favorable prognosis in glioblastoma multiforme (GBM) and has been hypothesized to occur early in tumor transformation of glial cells. Thus, a possible link exists between the site of malignant transformation and MGMT promoter methylation status. Using the Analysis of Differential Involvement (ADIFFI) statistical mapping technique in a total of 358 patients with GBM, we demonstrate that human de novo GBMs occur in a high frequency contiguous with the posterior subventricular zone (SVZ); MGMT promoter methylated GBMs are lateralized to the left hemisphere, while MGMT unmethylated GBMs are lateralized to the right hemisphere; and tumors near the left temporal lobe have a significantly longer overall survival compared with tumors occurring elsewhere, independent of treatment or MGMT methylation status. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：908 / 916

页数：9

共 46 条

[1] Neurogenesis in adult subventricular zone [J].

Alvarez-Buylla, A ;

García-Verdugo, JM .

JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :629-634

[2] GROWTH-REGULATION OF HUMAN GLIOBLASTOMA T98G CELLS BY INSULIN-LIKE GROWTH-FACTOR-I AND ITS RECEPTOR [J].

AMBROSE, D ;

RESNICOFF, M ;

COPPOLA, D ;

SELL, C ;

MIURA, M ;

JAMESON, S ;

BASERGA, R ;

RUBIN, R .

JOURNAL OF CELLULAR PHYSIOLOGY, 1994, 159 (01) :92-100

[3] Asymmetry in the human motor cortex and handedness [J].

Amunts, K ;

Schlaug, G ;

Schleicher, A ;

Steinmetz, H ;

Dabringhaus, A ;

Roland, PE ;

Zilles, K .

NEUROIMAGE, 1996, 4 (03) :216-222

[4] Relationship of gliomas to the ventricular walls [J].

Barami, Kaveh ;

Sloan, Andrew E. ;

Rojiani, Amyn ;

Schell, Michael J. ;

Staller, Aileen ;

Brem, Steven .

JOURNAL OF CLINICAL NEUROSCIENCE, 2009, 16 (02) :195-201

[5] Voxel-based lesion-symptom mapping [J].

Bates, E ;

Wilson, SM ;

Saygin, AP ;

Dick, F ;

Sereno, MI ;

Knight, RT ;

Dronkers, NF .

NATURE NEUROSCIENCE, 2003, 6 (05) :448-450

[6]

Borod Joan C, 2002, Appl Neuropsychol, V9, P23, DOI 10.1207/S15324826AN0901_4

[7]

Broca Paul, 1861, Bulletin et Memoires de La Societe Anatomique de Paris, V6, P330, DOI DOI 10.1093/ACPROF:OSO/9780195177640.003.0018

[8] Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain [J].

Bullmore, ET ;

Suckling, J ;

Overmeyer, S ;

Rabe-Hesketh, S ;

Taylor, E ;

Brammer, MJ .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 1999, 18 (01) :32-42

[9] INDUCTION OF INTRACRANIAL NEOPLASMS BY INOCULATION OF AVIAN-SARCOMA VIRUS IN PERINATAL AND ADULT RATS [J].

COPELAND, DD ;

VOGEL, FS ;

BIGNER, DD .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1975, 34 (04) :340-358

[10]

Cox RW, 1999, MAGNET RESON MED, V42, P1014, DOI 10.1002/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO

← 1 2 3 4 5 →