Cellular signaling and biological functions of R-spondins

被引：74
|
作者：
Yoon, Jeong Kyo [1 ]
Lee, Jin-Seon [1 ]
机构：
[1] Maine Med Ctr, Ctr Mol Med, Program Stem Cell & Regenerat Med, Res Inst, Scarborough, ME 04074 USA
来源：
CELLULAR SIGNALLING | 2012年 / 24卷 / 02期
关键词：
R-spondin; WNT signaling; Cellular signaling; Biological function; AUTOSOMAL-RECESSIVE ANONYCHIA; RECEPTOR-RELATED PROTEIN-5; APICAL ECTODERMAL RIDGE; MOUSE MAMMARY-TUMORS; DORSAL NEURAL-TUBE; HIGH BONE-DENSITY; BETA-CATENIN; STEM-CELLS; INHERITED ANONYCHIA; COLORECTAL-CANCER;
D O I：
10.1016/j.cellsig.2011.09.023
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
R-spondins (RSPOs) are a family of cysteine-rich secreted proteins containing a single thrombospondin type I repeat (TSR) domain. A vast amount of information regarding cellular signaling and biological functions of RSPOs has emerged over the last several years, especially with respect to their roles in the activation of the WNT signaling pathway. The identification of several classes of RSPO receptors may indicate that this family of proteins can affect several signaling cascades. Herein, we summarize the current understanding of RSPO signaling and its biological functions, and discuss its potential therapeutic implications to human diseases. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：369 / 377
页数：9
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