A multi-drug delivery system with sequential release using titania nanotube arrays

被引:104
作者
Aw, Moom Sinn [1 ]
Addai-Mensah, Jonas [1 ]
Losic, Dusan [1 ,2 ]
机构
[1] Univ S Australia, Ian Wark Res Inst, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
基金
澳大利亚研究理事会;
关键词
DRUG-DELIVERY; BONE CEMENTS;
D O I
10.1039/c2cc17690d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A multi-drug delivery system with sequential release based on titania nanotube arrays and polymer micelles as drug carriers is presented. Delivery of multiple water insoluble and soluble drugs required for combined local therapy is demonstrated.
引用
收藏
页码:3348 / 3350
页数:3
相关论文
共 27 条
[1]   Drug delivery systems: Entering the mainstream [J].
Allen, TM ;
Cullis, PR .
SCIENCE, 2004, 303 (5665) :1818-1822
[2]  
[Anonymous], 1988, ADV DRUG DELIVER REV, V1, P199
[3]   Polymeric micelles in porous and nanotubular implants as a new system for extended delivery of poorly soluble drugs [J].
Aw, Moom Sinn ;
Simovic, Spomenka ;
Addai-Mensah, Jonas ;
Losic, Dusan .
JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (20) :7082-7089
[4]   Microfabrication technology for pancreatic cell encapsulation [J].
Desai, TA .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2002, 2 (06) :633-646
[5]   Self-ordering electrochemistry: a review on growth and functionality of TiO2 nanotubes and other self-aligned MOx structures [J].
Ghicov, Andrei ;
Schmuki, Patrik .
CHEMICAL COMMUNICATIONS, 2009, (20) :2791-2808
[6]   Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion [J].
Gulati, Karan ;
Ramakrishnan, Saminathan ;
Aw, Moom Sinn ;
Atkins, Gerald J. ;
Findlay, David M. ;
Losic, Dusan .
ACTA BIOMATERIALIA, 2012, 8 (01) :449-456
[7]   Local drug delivery [J].
Haroun, RI ;
Brem, H .
CURRENT OPINION IN ONCOLOGY, 2000, 12 (03) :187-193
[8]  
Langer R, 2001, SCIENCE, V293, P58, DOI 10.1126/science.1063273
[9]   Developing a new generation of bone cements with nanotechnology [J].
Liu-Snyder, Peishan ;
Webster, Thomas J. .
CURRENT NANOSCIENCE, 2008, 4 (01) :111-118
[10]   Self-ordered nanopore and nanotube platforms for drug delivery applications [J].
Losic, Dusan ;
Simovic, Spomenka .
EXPERT OPINION ON DRUG DELIVERY, 2009, 6 (12) :1363-1381