Hepatitis E virus treatment and ribavirin therapy: viral mechanisms of nonresponse

被引：53

作者：

Todt, Daniel ^{[1
]}

Meister, Toni Luise ^{[1
]}

Steinmann, Eike ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Mol & Med Virol, Bochum, Germany

来源：

CURRENT OPINION IN VIROLOGY | 2018年 / 32卷

关键词：

GENOTYPE; 3; IN-VITRO; INFECTION; REPLICATION; PATIENT; BLOOD; SOFOSBUVIR; MUTATIONS; PROTEIN; REGION;

D O I：

10.1016/j.coviro.2018.10.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) can cause chronic infections in immunosuppressed patients with adverse clinical outcomes. Intervention strategies are limited with ribavirin (RBV) being the only main therapeutic option as off-label drug. Recent reports on RBV monotherapy failures show a coherence with the presence of certain single nucleotide variants (SNVs) and in-frame insertions in the hypervariable region of open reading frame 1 in the HEV genome. Importantly, some of the alterations were present in the viral population as minor variant before RBV administration. Individualized infection medicine by early detection of emerging viral variants in patients could improve treatment outcome and prognosis.

引用

页码：80 / 87

页数：8

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