The Cell Biology of Synaptic Plasticity

被引：430
作者：
Ho, Victoria M. [2 ]
Lee, Ji-Ann [1 ]
Martin, Kelsey C. [1 ,3 ,4 ]
机构：
[1] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Interdept Program Neurosci, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA
来源：
SCIENCE | 2011年 / 334卷 / 6056期
关键词：
LONG-TERM POTENTIATION; DENDRITIC PROTEIN-SYNTHESIS; II MUTANT MICE; AMPA RECEPTORS; TRANSLATIONAL CONTROL; MESSENGER-RNA; CYTOPLASMIC POLYADENYLATION; DEPENDENT TRANSLATION; RECYCLING ENDOSOMES; HIPPOCAMPAL-NEURONS;
D O I：
10.1126/science.1209236
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.
引用
收藏
页码：623 / 628
页数：6
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