Recombinant vaccines for hepatitis E

被引：67
作者：
Emerson, SU
Purcell, RH
机构：
[1] NIAID, Mol Hepatitis Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
[2] NIAID, Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 10期
关键词：
D O I：
10.1016/S1471-4914(01)02106-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatitis E virus causes epidemics of acute hepatitis in many developing countries. It infrequently causes disease in developed countries, but avirulent strains might circulate. Some evidence suggests that hepatitis E might be a zoonosis. There is probably only a single serotype. A candidate vaccine consisting of baculovirus-expressed recombinant capsid protein protected macaques from hepatitis E - it passed phase I clinical trials and is currently scheduled for phase II/III clinical trials.
引用
收藏
页码：462 / 466
页数：5
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