An 8-year study of depression effects on myocardial infarction risk in a population of 25-64 year old men

Aim. To study depression effects on the risk of myocardial infarction (MI) for 8 years in men aged 25-64 years. Material and methods. A random representative sample of men (n = 657) at the age between 25 and 64 living in Novosibirsk were screened in 1994 in the scope of WHO program 'MONICA-psychosocial", The response was 82.1%. WHO "Register of Acute Myocardial Infarction" detected 58 cases of MI in the control period 1994-2002. Statistics were obtained with the program set SPSS-10. Cox regression model was used for estimation of a relative MI risk (RMIR). Results. RMIR in 25-64-year-old men for 8 years was 2-fold higher in men with depression than without it, in the age group of 55-64-old men-5-fold. Depression was in 65.8% MI patients. The highest RMIR was in men with depression engaged in hard labour, retired, poorly educated, divorced, widowed. Conclusion. Risk of MI in men is related to depression due to social and economic status.