Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness

被引：8

作者：

Takemiya, Takako ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Med Res Inst, Shinjuku Ku, Tokyo 1628666, Japan

来源：

NEUROCHEMISTRY INTERNATIONAL | 2011年 / 59卷 / 06期

关键词：

Prostaglandin E-2; Microsomal prostaglandin E synthase-1(mPGES-1); mPGES-1 knockout mice; Sleepiness; RATS;

D O I：

10.1016/j.neuint.2011.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study examined the effect of prostaglandin E-2 (PGE(2)) produced by microsomal prostaglandin E synthase-1 (mPGES-1) on circadian rhythm. Using wild-type mice (WT) and mPGES-1 knockout mice (mPGES-1(-/-)), I recorded and automatically analyzed the natural behavior of mice in home cages for 24 h and measured brain levels of PGE(2). The switch to wakefulness was not smooth, and sleepiness and the total duration of sleep were significantly longer in the mPGES-1(-/-) mice. Moreover, the basal concentration of PGE(2) was significantly lower in the mPGES-1(-/-) mice. These findings suggest that PGE(2) produced by mPGES-1 regulates the onset of wakefulness and the maintenance of circadian rhythm. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：922 / 924

页数：3

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