"Cofactor"-Controlled Enantioselective Catalysis

被引：98
|
作者：
Dydio, Pawel [1 ]
Rubay, Christophe [1 ]
Gadzikwa, Tendai [1 ]
Lutz, Martin [2 ]
Reek, Joost N. H. [1 ]
机构：
[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1098 XH Amsterdam, Netherlands
[2] Univ Utrecht, Bijvoet Ctr Biomol Res, NL-3584 CH Utrecht, Netherlands
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 43期
关键词：
SUPRAMOLECULAR CATALYSIS; SIGNAL AMPLIFICATION; BIDENTATE LIGANDS; HIGH-THROUGHPUT; TRANSITION; CHEMISTRY; MODELS; RECEPTORS; LIBRARIES; DESIGN;
D O I：
10.1021/ja208589c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report an achiral bisphosphine rhodium complex with a binding site for the recognition of chiral anion guests. Upon binding small chiral guests-cofactors-the rhodium complex becomes chiral and can thus be used for asymmetric catalysis. Screening of a library of cofactors revealed that the best cofactors lead to hydrogenation catalysts that form the products with high enantioselectivity (ee's up to 99%). Interestingly, a competition experiment shows that even in a mixture of 12 cofactors high ee is obtained, indicating that the complex based on the best cofactor dominates the catalysis.
引用
收藏
页码：17176 / 17179
页数：4
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