"Cofactor"-Controlled Enantioselective Catalysis

被引：99

作者：

Dydio, Pawel ^{[1
]}

Rubay, Christophe ^{[1
]}

Gadzikwa, Tendai ^{[1
]}

Lutz, Martin ^{[2
]}

Reek, Joost N. H. ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1098 XH Amsterdam, Netherlands

[2] Univ Utrecht, Bijvoet Ctr Biomol Res, NL-3584 CH Utrecht, Netherlands

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 43期

关键词：

SUPRAMOLECULAR CATALYSIS; SIGNAL AMPLIFICATION; BIDENTATE LIGANDS; HIGH-THROUGHPUT; TRANSITION; CHEMISTRY; MODELS; RECEPTORS; LIBRARIES; DESIGN;

D O I：

10.1021/ja208589c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report an achiral bisphosphine rhodium complex with a binding site for the recognition of chiral anion guests. Upon binding small chiral guests-cofactors-the rhodium complex becomes chiral and can thus be used for asymmetric catalysis. Screening of a library of cofactors revealed that the best cofactors lead to hydrogenation catalysts that form the products with high enantioselectivity (ee's up to 99%). Interestingly, a competition experiment shows that even in a mixture of 12 cofactors high ee is obtained, indicating that the complex based on the best cofactor dominates the catalysis.

引用

页码：17176 / 17179

页数：4

共 42 条

[1] Supramolecular approaches to generate libraries of chelating bidentate ligands for homogeneous catalysis [J].