β1-Integrin/matrix interactions support blood-brain barrier integrity

被引：30

作者：

Engelhardt, Britta ^{[1
]}

机构：

[1] Univ Bern, Theodor Kocher Inst, CH-3012 Bern, Switzerland

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2011年 / 31卷 / 10期

关键词：

beta; 1-integrin; blood-brain barrier; claudin-5; extracellular matrix; tight junction; GLIOBLASTOMA-MULTIFORME; HEMORRHAGE;

D O I：

10.1038/jcbfm.2011.98

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brain microvascular endothelium forms an active permeability barrier, the blood-brain barrier (BBB). In neurologic disorders, barrier properties of the BBB are often lost indicating their dependance on molecular cues of the brain microenvironment. In this issue, Osada et al demonstrate that the endothelial extracellular matrix (ECM) provides one of these cues. Their study shows that beta 1-integrin-mediated adhesion of brain endothelial cells to the surrounding ECM is critical for stabilizing claudin-5 in BBB tight junctions (TJs) and BBB integrity. These observations point to a novel intracellular signaling pathway from beta 1-integrin/ECM endothelial adhesions to BBB TJs contributing to BBB integrity. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 1969-1971; doi:10.1038/jcbfm.2011.98; published online 20 July 2011

引用

页码：1969 / 1971

页数：3