From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma

被引：413

作者：

Ratushny, Vladimir ^{[1
]}

Gober, Michael D. ^{[1
]}

Hick, Ryan ^{[1
]}

Ridky, Todd W. ^{[1
]}

Seykora, John T. ^{[1
]}

机构：

[1] Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 02期

关键词：

ABL TYROSINE KINASE; GENE NUMERICAL ABERRATIONS; NONMELANOMA SKIN-CANCER; ACTINIC KERATOSIS; P53; MUTATIONS; EPIDERMAL-GROWTH; TUMOR-SUPPRESSOR; STEM-CELLS; C-DELTA; MALIGNANT-TRANSFORMATION;

D O I：

10.1172/JCI57415

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with over 250,000 new cases annually in the US and is second in incidence only to basal cell carcinoma. cSCC typically manifests as a spectrum of progressively advanced malignancies, ranging from a precursor actinic keratosis (AK) to squamous cell carcinoma (SCC) in situ (SCCIS), invasive cSCC, and finally metastatic SCC. In this Review we discuss clinical and molecular parameters used to define this range of cutaneous neoplasia and integrate these with the multiple experimental approaches used to study this disease. Insights gained from modeling cSCCs have suggested innovative therapeutic targets for treating these lesions.

引用

页码：464 / 472

页数：9

共 110 条

[1]

AHO M, 1991, CANCER, V68, P195, DOI 10.1002/1097-0142(19910701)68:1<195::AID-CNCR2820680135>3.0.CO

[2]

2-L

[3] The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer [J].

Almquist, Lindsay M. ;

Karagas, Margaret R. ;

Christensen, Brock C. ;

Welsh, Marleen M. ;

Perry, Ann E. ;

Storm, Craig A. ;

Nelson, Heather H. .

CARCINOGENESIS, 2011, 32 (03) :327-330

[4] Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders [J].

Ayli, Elias E. ;

Li, Weijie ;

Brown, Tamu T. ;

Witkiewicz, Agnieszka ;

Elenitsas, Rosalie ;

Seykora, John T. .

JOURNAL OF CUTANEOUS PATHOLOGY, 2008, 35 (03) :273-277

[5] SKIN HYPERKERATOSIS AND PAPILLOMA FORMATION IN TRANSGENIC MICE EXPRESSING A RAS ONCOGENE FROM A SUPRABASAL KERATIN PROMOTER [J].

BAILLEUL, B ;

SURANI, MA ;

WHITE, S ;

BARTON, SC ;

BROWN, K ;

BLESSING, M ;

JORCANO, J ;

BALMAIN, A .

CELL, 1990, 62 (04) :697-708

[6]

BAKER SJ, 1990, CANCER RES, V50, P7717

[7] The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website [J].

Bamford, S ;

Dawson, E ;

Forbes, S ;

Clements, J ;

Pettett, R ;

Dogan, A ;

Flanagan, A ;

Teague, J ;

Futreal, PA ;

Stratton, MR ;

Wooster, R .

BRITISH JOURNAL OF CANCER, 2004, 91 (02) :355-358

[8] Expression of multiple cytochrome P450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes [J].

Baron, JM ;

Höller, D ;

Schiffer, R ;

Frankenberg, S ;

Neis, M ;

Merk, HF ;

Jugert, FK .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 116 (04) :541-548

[9] Skin cancer in organ transplant recipients: Epidemiology, pathogenesis, and management [J].

Berg, D ;

Otley, CC .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 47 (01) :1-17

[10] Non-melanoma skin cancer: what drives tumor development and progression? [J].

Boukamp, P .

CARCINOGENESIS, 2005, 26 (10) :1657-1667

← 1 2 3 4 5 6 7 8 9 10 →